Anodic TiO2 nanotubular arrays with pre-synthesized hydroxyapatite--an effective approach to enhance the biocompatibility of titanium.

Anodic TiO2 nanotubular arrays with pre-synthesized hydroxyapatite--an effective approach to enhance the biocompatibility of titanium.

Journal of nanoscience and nanotechnology (2013-07-26)

Lu-Ning Wang, Long-Xiang Lin, Chang-Jian Lin, Chen Shen, Alyssa Shinbine, Jing-Li Luo

ZUSAMMENFASSUNG

Electrochemically anodized TiO2 nanotubular arrays can provide large surface areas for biological species attachment. In order to further enhance the biocompatibility of Ti medical implants, we deposited a pre-synthesized hydroxyapatite inside and on the nanotubular arrays, and examined the biocompatibility of the anodized TiO2 nanotubular arrays with pre-synthesized hydroxyapatite by in vitro assessment in simulated body fluid, and in vitro cell culture. The results showed that the hydroxyapatite coating was able to be induced on TiO2 nanotubular arrays with pre-synthesized hydroxyapatite within 5 days while only a thin film composed of calcium phosphorous chemicals formed on as-formed TiO2 nanotubular arrays. The cell culture evaluation further proved the enhancement of cell attachment and proliferation on TiO2 nanotubular arrays with pre-synthesized hydroxyapatite as opposed to those without pre-synthesized hydroxyapatite. The present study proves that formation of TiO2 nanotubular arrays with pre-synthesized hydroxyapatite a promising method to enhance the biocompatibility of Ti implants.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

718467

Sigma-Aldrich

Titan(IV)-oxid, nanopowder, 21 nm primary particle size (TEM), ≥99.5% trace metals basis

637254

Sigma-Aldrich

Titan(IV)-oxid, Anatase, nanopowder, <25 nm particle size, 99.7% trace metals basis

232033

Sigma-Aldrich

Titan(IV)-oxid, Anatase, powder, 99.8% trace metals basis

14021

Sigma-Aldrich

Titan(IV)-oxid, ReagentPlus^®, ≥99%

248576

Sigma-Aldrich

Titan(IV)-oxid, Anatase, powder, −325 mesh, ≥99% trace metals basis

224227

Sigma-Aldrich

Titan(IV)-oxid, Rutil, powder, <5 μm, ≥99.9% trace metals basis

637262

Sigma-Aldrich

Titan(IV)-oxid, Rutil, nanopowder, <100 nm particle size, 99.5% trace metals basis

634662

Sigma-Aldrich

Titan(IV)-oxid, Mischung aus Rutil und Anatas, nanopowder, <100 nm particle size (BET), 99.5% trace metals basis

348791

Sigma-Aldrich

Titan, foil, thickness 0.127 mm, 99.7% trace metals basis

267503

Sigma-Aldrich

Titan, foil, thickness 0.25 mm, 99.7% trace metals basis

366994

Sigma-Aldrich

Titan, powder, <45 μm avg. part. size, 99.98% trace metals basis

268496

Sigma-Aldrich

Titan, powder, −100 mesh, 99.7% trace metals basis

700347

Sigma-Aldrich

Titan(IV)-oxid, Mischung aus Rutil und Anatas, nanoparticles, <150 nm particle size (volume distribution, DLS), dispersion, 40 wt. % in H₂O, 99.5% trace metals basis

204757

Sigma-Aldrich

Titan(IV)-oxid, Rutil, ≥99.98% trace metals basis

04238

Sigma-Aldrich

Hydroxylapatit, puriss., meets analytical specification of Ph. Eur., BP, FCC, E341, ≥90% (calculated on glowed substance)

204730

Sigma-Aldrich

Titan(IV)-oxid, Rutil, 99.995% trace metals basis

21223

Sigma-Aldrich

Hydroxylapatit, purum p.a., ≥90% (as Ca₃(PO₄)₂, KT)