F0807

Anti-FNTB (276-290) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinônimo(s): Anti-FPTB, Anti-Farnesyltransferase subunit β
• UNSPSC Code: 12352203

Propriedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~49 kDa
• species reactivity: human
• technique(s): western blot: 1:500-1:2,000
• UniProt accession no.: P49356
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... FNTB(2342)

Descrição

Immunogen

synthetic peptide corresponding to amino acids 276-290 of human FNTB

Application

Anti-FNTB (276-290) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

Protein farnesyltransferase subunit β is an enzyme encoded by the FNTB gene in humans and is located on human chromosome bands 14q23-q24. It helps in catalyzing the biologically relevant lipidation of cellular proteins. FTase may play an important role in the genesis and development of primary liver cancer (PLC). It may act as a reliable marker for the metastatic activity gained by liver tumor cells. FTase may be used clinically in predicting metastatic recurrence of PLC. Farnesyl protein transferase (FPTase) inhibitors (FTIs) were also developed as potential anticancer agents targeting the ras oncogene and also for parasitic infections.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.