Alcohol and oral squamous cell carcinoma.

Alcohol and oral squamous cell carcinoma.

SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging (2013-08-27)

L Feller, R Chandran, R A G Khammissa, R Meyerov, J Lemmer

PMID23971298

ZUSAMMENFASSUNG

Alcohol is a risk factor for oral squamous cell carcinoma. It enhances the permeability of the oral epithelium, acts as a solvent for tobacco carcinogens, induces basal-cell proliferation, and generates free radicals and acetaldehyde, which have the capacity to cause DNA damage. Alcohol-associated malnutrition and immune suppression may further promote carcinogenesis. However, acetaldehyde, the first metabolite of ethanol, is the critical agent by which prolonged and excessive consumption of alcoholic beverages increases the risk of oral squamous cell carcinoma. Alcohol also acts synergistically with the products of tobacco combustion in the pathogenesis of oral squamous cell carcinoma.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

E7023

Sigma-Aldrich

Ethyl alcohol, Pure 200 proof, Molecular Biology

459844

Sigma-Aldrich

Ethyl alcohol, Pure, 200 proof, ACS reagent, ≥99.5%

493546

Sigma-Aldrich

Ethyl alcohol, Pure, 200 proof, meets USP testing specifications

459836

Sigma-Aldrich

Ethyl alcohol, Pure, 200 proof, anhydrous, ≥99.5%

493511

Sigma-Aldrich

Ethyl alcohol, Pure, 190 proof, ACS spectrophotometric grade, 95.0%

402788

Sigma-Aldrich

Acetaldehyd, ACS reagent, ≥99.5%

02870

Sigma-Aldrich

Ethanol, ACS reagent, prima fine spirit, without additive, F15 o¹

W200336

Sigma-Aldrich

Acetaldehyd, natural, FG

51976

Sigma-Aldrich

Ethanol, BioUltra, Molecular Biology, ≥99.8%, (absolute alcohol, without additive, A15 o¹)

02856

Sigma-Aldrich

Ethanol, purum, absolute ethanol, denaturated with 4.8% isopropanol, A15 IPA¹, ≥99.8% (based on denaturant-free substance)

00070

Sigma-Aldrich

Acetaldehyd, puriss. p.a., anhydrous, ≥99.5% (GC)

PHR1070

Supelco

Ethanol, wasserfrei, Pharmaceutical Secondary Standard; Certified Reference Material

02483

Supelco

Ethanol, standard for GC

02857

Sigma-Aldrich

Ethanol, purum, fine spirit, denaturated with 4.8% methanol, F25 METHYL¹, ~96% (based on denaturant-free substance)

506788

Supelco

Acetaldehyd, PESTANAL^®, analytical standard

00071

Sigma-Aldrich

Acetaldehyd, ReagentPlus^®, ≥99.0% (GC)

E-029

Supelco

Ethanol-50, 50 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

E-033

Supelco

Ethanol-300, 300 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

277649

Sigma-Aldrich

Reagent Alcohol, anhydrous, ≤0.003% water

W200328

Sigma-Aldrich

Acetaldehyd -Lösung, 50 wt. % in ethanol

E-040

Supelco

Ethanol-10, 10 mg/dL in H₂O, pack of 10 × 1.2 mL ampules, certified reference material, Cerilliant^®

W200379

Sigma-Aldrich

Acetaldehyd -Lösung, 40 wt. % in H₂O

E-030

Supelco

Ethanol-80, 80 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

E-031

Supelco

Ethanol-100 (10 Ampullen/Kit), 100 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

02890

Sigma-Aldrich

Ethanol, purum, fine spirit, denaturated with 2% 2-butanone, F25 MEK¹, ~96% (based on denaturant-free substance)

02851

Sigma-Aldrich

Ethanol

676829

Sigma-Aldrich

Reagent Alcohol, anhydrous, ≤0.005% water

29221

Sigma-Aldrich

Ethanol, tested according to Ph. Eur.

E-053

Supelco

Ethanol-500, 500 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

E-041

Supelco

Ethanol-150, 150 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®