This material should be stored refrigerated temperature at 2 - 8 °C. The product is assigned a retest date of approximately 2 years from the date of Quality release. The quality of this item cannot be quatanteed if stored outside of the recommended conditions for extended periods. Please see the link below to review the lot specific Certificate of Analysis to determine retest date:
https://www.sigmaaldrich.com/product/sigma/h8502#product-documentation
H8502
Dopamine hydrochloride
≥98% (TLC), powder, neurotransmitter
Sinonimo/i:
2-(3,4-Dihydroxyphenyl)ethylamine hydrochloride, 3,4-Dihydroxyphenethylamine hydrochloride, 3-Hydroxytyramine hydrochloride, 4-(2-Aminoethyl)-1,2-benzenediol hydrochloride
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5 G
CHF 52.90
10 G
CHF 102.00
25 G
CHF 178.00
100 G
CHF 639.00
Informazioni su questo articolo
Formula condensata:
(HO)2C6H3CH2CH2NH2·HCl
Numero CAS:
Peso molecolare:
189.64
Beilstein:
3656720
Numero CE:
Numero MDL:
Codice UNSPSC:
12352116
ID PubChem:
NACRES:
NA.77
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Servizio Tecnico
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Permettici di aiutartiNome del prodotto
Dopamine hydrochloride,
Stato
powder
Livello qualitativo
Colore
, White to Light Yellow to Light Beige
Punto di fusione
248-250 °C (lit.)
Solubilità
alcohol: 20 mg/mL
H2O: soluble
Temperatura di conservazione
2-8°C
Stringa SMILE
Cl[H].NCCc1ccc(O)c(O)c1
InChI
1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H
CTENFNNZBMHDDG-UHFFFAOYSA-N
Informazioni sul gene
human ... ADRB1(153)
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1 of 4
Questo articolo | PHR1090 | 1225204 | 43658 |
|---|---|---|---|
| form powder | form - | form - | form powder |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level 300 |
| storage temp. 2-8°C | storage temp. 2-30°C | storage temp. - | storage temp. 2-8°C |
| solubility alcohol: 20 mg/mL, H2O: soluble | solubility - | solubility - | solubility - |
| color light tan | color - | color - | color - |
| mp 248-250 °C (lit.) | mp 248-250 °C (lit.) | mp 248-250 °C (lit.) | mp 248-250 °C (lit.) |
Descrizione generale
Dopamine (DA) works as a neurotransmitter in the central nervous system.[1] It is a catecholamine made from the amino acid L-tyrosine. It also works as a hormone in the vesicles of the adrenal medulla, thereby controlling heart beat rate and blood pressure. The Absence of DA-containing neurons is associated with Parkinson’s disease.[2]Dopamine is produced and released by the dopaminergic neurons in the substantia nigra that is in the central nervous system.[3] It is involved in several activities such as movement, behaviour, learning, reward, punishment, dreaming, working, memory, mood, sleep, attention, and inhibition of prolactin production. Dopamine also acts as a precursor in the synthesis of catecholamines like epinephrine and norepinephrine.[4] Increased levels of dopamine via the tuberoinfundibular pathway are associated with Schizophrenia, hallucinations, euphoria, and psychosis.[4] A deficiency of dopamine and norepinephrine indicates the neurochemical basis for attention-deficit hyperactivity disorder (ADHD), a pediatric disorder.[5]
Applicazioni
Dopamine hydrochloride has been used:
- to study dopamine-mediated transient modulation of the physiological responses in white leg shrimp, Litopenaeus vannamei.[6]
- to study dopamine-mediated changes in immunity susceptibility to Lactococcus garvieae in the freshwater giant prawn, Macrobrachium rosenbergii.[7]
- to study the molecular link between dopamine-induced oxidative stress and mHtt (mutant Huntingtin) toxicity in relation to the activation of the autophagy pathway in an ‘in vitro’ model of parkinsonian Huntington′s Disease.[8]
- as a substrate of the prophenoloxidase (PPO) cascade reaction in the anti-microbial assay targeting methicillin-resistant staphylococcus aureus (MRSA) in the biofilm phase.[9]
- added exogenously to the culture medium to study its effect on H. contortus female worms.[10]
Caratteristiche e vantaggi
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Esclusione di responsabilità
Light sensitive
Prodotti correlati
N° Catalogo
Descrizione
Determinazione del prezzo
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Skin Sens. 1
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Saad Latif et al.
Clinica chimica acta; international journal of clinical chemistry, 522, 114-126 (2021-08-15)
Parkinson's disease is a neurodegenerative disease caused by the death of neurons, ie, cells critical to the production of dopamine, an important neurotransmitter in the brain. Here, we present a brief review of the dopamine synthetic pathway, binding to the
Dopamine depresses the immune ability and increases susceptibility to Lactococcus garvieae in the freshwater giant prawn, Macrobrachium rosenbergii.
Li JT et al.
Fish & Shellfish Immunology, 19, 269-269 (2005)
Rafael Franco et al.
Biomedicines, 9(2) (2021-01-28)
Dopamine is derived from an amino acid, phenylalanine, which must be obtained through the diet. Dopamine, known primarily to be a neurotransmitter involved in almost any higher executive action, acts through five types of G-protein-coupled receptors. Dopamine has been studied
Flow injection with inhibited chemiluminescence method for the determination of dopamine hydrochloride.
Shuhao WANG et al.
Analytical Sciences, 20, 315-317 (2004)
Peripheral Dopamine Controlled by Gut Microbes Inhibits Invariant Natural Killer T Cell-Mediated Hepatitis
Xue R, et al.
Frontiers in Immunology, 9, 2398-2398 (2018)
Articoli
DISCOVER Bioactive Small Molecules for Neuroscience
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How long can it be stored? I found two in our lab, but one at room temperature for years and another one in 10 oC fridge.
1 answer-
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Upon dissolving the H8502 powder, the solution turned dark purple/black. What could be the cause of this discoloration? Can the product still be considered suitable for use?
Upon dissolving the H8502 powder, the solution turned dark purple/black. What could be the cause of this discoloration? Can the product still be considered suitable for use?
1 answer-
Regarding the solubility of product H8502, it can be dissolved in alcohol at a concentration of 20 mg/mL or in water (H2O) at 100 mg/mL. It is recommended that solutions be prepared fresh and not stored for long-term use. Preparing aliquots for storage at -20°C or keeping the product in solution at 4-8°C is not advised.
Dopamine, the active component, is sensitive to light and the free base form is particularly prone to oxidation. Solutions with a pH range of 5.4 to 6.8 have been reported to remain stable for a maximum of 48 hours at 25°C, beyond which the solution may darken and become unusable.
Dopamine solutions should not be mixed with alkalis, iron salts, or oxidizing agents, and are known to be incompatible with certain antibiotics, including amphotericin, ampicillin, gentamicin sulfate, and benzylpenicillin.
In the literature, you can find some articles where the stability of this compound is indicated. For example: https://www.ncbi.nlm.nih.gov/pubmed/14651669
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Is this product analytical standard that can be used in LCMSMS to quantify the amount of Dopamine?
1 answer-
Unfortunately, this product is not tested as an analytical standard for use in LCMSMS.
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Can it be stored at -20C
1 answer-
The recommended storage temperature for this product is 2-8°C. In general, powder materials are not affected by freezer storage, however, this item has not been tested under these storage conditions.
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