For ATPase, a 0.5-1 μM concentration of sodium orthovanadate inhibited 50% of the activity. Please see the product information sheet (under Documents, above) which provides references on several other enzymes.
S6508
Sodium orthovanadate
synthetic (organic), ≥90% (titration), protein tyrosine phosphatase inhibitor, crystalline powder
Sinonimo/i:
Trisodium vanadate
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10 G
CHF 80.50
50 G
CHF 310.00
250 G
CHF 536.00
Informazioni su questo articolo
Formula condensata:
Na3VO4
Numero CAS:
Peso molecolare:
183.91
Numero CE:
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
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Permettici di aiutartiNome del prodotto
Sodium orthovanadate, ≥90% (titration)
Origine biologica
synthetic (organic)
Saggio
≥90% (titration)
Stato
crystalline powder
Impiego in reazioni chimiche
reagent type: catalyst
core: vanadium
Colore
white to off-white
Punto di fusione
850-866 °C (lit.)
Solubilità
H2O: soluble
Stringa SMILE
[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O
InChI
1S/3Na.4O.V/q3*+1;;3*-1;
IHIXIJGXTJIKRB-UHFFFAOYSA-N
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Categorie correlate
1 of 4
Questo articolo | 567540 | 450243 | 74875 |
|---|---|---|---|
| assay ≥90% (titration) | assay - | assay 99.98% trace metals basis | assay ≥90% (HPCE) |
| form crystalline powder | form solid | form solid | form powder |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
| solubility H2O: soluble | solubility water: 10 mg/mL | solubility - | solubility DMF: soluble, DMSO: soluble, H2O: soluble, methanol: soluble |
| color white to off-white | color white to off-white | color - | color - |
| biological source synthetic (organic) | biological source - | biological source - | biological source - |
Applicazioni
Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase.26 It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.27
Azioni biochim/fisiol
Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release from endocrine cells and blocks IP3 binding to its receptor in brain tissue.
Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.24 In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.25
Caratteristiche e vantaggi
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Avvertenze
Warning
Indicazioni di pericolo
Classi di pericolo
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Codice della classe di stoccaggio
13 - Non Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Contenuto correlato
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What is the amount of S6508, Sodium orthovanadate, needed for inhibition?
1 answer-
Helpful?
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Which enzymes does S6508 inhibit?
1 answer-
Sodium orthovanadate is an inhibitor of ATPase, alkaline phosphatase and tyrosine phosphatase.
Helpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How do I store solutions of Product S6508, Sodium Orthovanadate?
1 answer-
Solutions of Product S6508, Sodium Orthovanadate, prepared as 1 mM in water (or higher if desired) and adjusted down to pH 10 can be aliquotted in plastic tubes and stored at -20°C. To ensure the presence of monomers, solutions should be heated to boiling until translucent and pH readjusted to 10. View the product information sheet (under Documents, above), which has more details.
Helpful?
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How do I prepare solutions of Product S6508, Sodium Orthovanadate?
1 answer-
Solutions of Product S6508, Sodium Orthovanadate, prepared as 1 mM in water (or higher if desired) and adjusted down to pH 10 can be aliquotted in plastic tubes and stored at -20°C. To ensure the presence of monomers, solutions should be heated to boiling until translucent and pH readjusted to 10. View the product information sheet (under Documents, above), which has more details.
Helpful?
-
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