Synthesis of caffeic acid phenethyl ester derivatives, and their cytoprotective and neuritogenic activities in PC12 cells.

Synthesis of caffeic acid phenethyl ester derivatives, and their cytoprotective and neuritogenic activities in PC12 cells.

Journal of agricultural and food chemistry (2014-05-21)

Haiming Shi, Dongsheng Xie, Ruoling Yang, Yaqian Cheng

ABSTRACT

Twenty-one caffeic acid phenethyl ester (CAPE) derivatives were synthesized, and characterized by IR, HR-MS, (1)H and (13)C NMR analyses. All compounds were evaluated for their cytoprotective effects against H2O2-induced cytotoxicity and neuritogenic activities in the neurite outgrowth in PC12 cells. Compounds 1 and 20 exhibited stronger cytoprotective activities than their parent compound CAPE at 4 nM. Compounds 1, 4, 12 and 13 showed potential neuritogenic activities at 0.5 nM, while compounds 19 and 20 induced neurite outgrowth at 10 nM. The results from this study suggested that CAPE and its derivatives may be potential functional food ingredients for the prevention of neurodegenerative diseases.

MATERIALI

Numero di prodotto

Marchio

Descrizione del prodotto

D2650

Sigma-Aldrich

Dimetil solfossido, Hybri-Max^™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

472301

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Dimetil solfossido, ACS reagent, ≥99.9%

D8418

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Dimetil solfossido, Molecular Biology

34869

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Dimetil solfossido, suitable for HPLC, ≥99.7%

D2438

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Dimetil solfossido, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

216763

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Perossido di idrogeno, contains inhibitor, 30 wt. % in H₂O, ACS reagent

D5879

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Dimetil solfossido, ReagentPlus^®, ≥99.5%

276855

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Dimetil solfossido, anhydrous, ≥99.9%

H1009

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Perossido di idrogeno, 30 % (w/w) in H₂O, contains stabilizer

D4540

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Dimetil solfossido, ≥99.5% (GC), suitable for plant cell culture

41640

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Dimetil solfossido, puriss. p.a., ACS reagent, ≥99.9% (GC)

516813

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Perossido di idrogeno, 50 wt. % in H₂O, stabilized

41639

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Dimetil solfossido, BioUltra, Molecular Biology, ≥99.5% (GC)

31642

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Perossido di idrogeno, 30% (w/w), puriss. p.a., reag. ISO, reag. Ph. Eur.

88597

Millipore

Perossido di idrogeno, 3%, suitable for microbiology

95321

Supelco

Perossido di idrogeno, ≥30%, for trace analysis

323381

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Perossido di idrogeno, contains ~200 ppm acetanilide as stabilizer, 3 wt. % in H₂O

D1435

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Dimetil solfossido, meets EP testing specifications, meets USP testing specifications

H3410

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USP

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