B5016

Bepridil -hydrochlorid

Name: Bepridil -hydrochlorid
Brand: SIGMA
Price: 261 EUR
Availability: InStock

calcium channel blocker, powder

Synonym(e):

1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride

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100 MG

261,00 €

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Über diesen Artikel

Empirische Formel (Hill-System):

C₂₄H₃₄N₂O · HCl

CAS-Nummer:

68099-86-5

Molekulargewicht:

403.00

UNSPSC Code:

12352202

PubChem Substance ID:

24277824

NACRES:

NA.77

MDL number:

MFCD00065498

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Produktname

Bepridil -hydrochlorid, powder

SMILES string

Cl.CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3

InChI

1S/C24H34N2O.ClH/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22;/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;1H

InChI key

JXBBWYGMTNAYNM-UHFFFAOYSA-N

form

powder

originator

Johnson & Johnson

Quality Level

100

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Dieser Artikel	B2417	P4670	SML1261
Sigma-Aldrich B5016 Bepridil -hydrochlorid	Sigma-Aldrich B2417 Benzamil hydrochloride hydrate	Sigma-Aldrich P4670 Propafenon -hydrochlorid	Sigma-Aldrich SML1261 Asimadoline hydrochloride
form powder	form solid	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
originator Johnson & Johnson	originator -	originator Abbott	originator -
Gene Information human ... CACNA1A(773), CACNA1B(774), CACNA1C(775), CACNA1D(776), CACNA1E(777), CACNA1F(778), CACNA1G(8913), CACNA1H(8912), CACNA1I(8911), CACNA1S(779), CACNA2D1(781), CACNA2D2(9254), CACNA2D3(55799), CACNA2D4(93589), CACNB1(782), CACNB2(783), CACNB3(784), CACNB4(785), CACNG1(786), CACNG2(10369), CACNG3(10368), CACNG4(27092), CACNG5(27091), CACNG6(59285), CACNG7(59284), CACNG8(59283)	Gene Information human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340) mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278) rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)	Gene Information human ... ABCB1(5243), ADRB1(153), ADRB2(154), ADRB3(155), CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)	Gene Information -

Biochem/physiol Actions

Non-selective calcium channel blocker and class IV antiarrhythmic agent; inhibits Na⁺-Ca²⁺ exchange; inhibits growth of brain tumor cells in vitro.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Lagerklasse

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.

Stefan Mitterreiter et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(26), 8974-8983 (2010-07-02)

The two proteases beta-secretase and gamma-secretase generate the amyloid beta peptide and are drug targets for Alzheimer's disease. Here we tested the possibility of targeting the cellular environment of beta-secretase cleavage instead of the beta-secretase enzyme itself. beta-Secretase has an

Bepridil facilitates early termination of spiral-wave reentry in two-dimensional cardiac muscle through an increase of intercellular electrical coupling.

Hiroki Takanari et al.

Journal of pharmacological sciences, 115(1), 15-26 (2010-12-16)

Bepridil is effective for conversion of atrial fibrillation to sinus rhythm and in the treatment of drug-refractory ventricular tachyarrhythmias. We investigated the effects of bepridil on electrophysiological properties and spiral-wave (SW) reentry in a 2-dimensional ventricular muscle layer of isolated

Efficacy of low-dose bepridil for prevention of ventricular fibrillation in patients with Brugada syndrome with and without SCN5A mutation.

Masato Murakami et al.

Journal of cardiovascular pharmacology, 56(4), 389-395 (2010-07-14)

It has been reported that bepridil prevents ventricular fibrillation (VF) in patients with Brugada syndrome, but the comparative efficacy with and without mutation in the SCN5A gene has not been elucidated. The purpose of this study was to assess the

Screening of OATP1B1/3 and OCT1 inhibitors in cryopreserved hepatocytes in suspension.

Lassina Badolo et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 40(4), 282-288 (2010-04-13)

Drug-drug interactions involving hepatic drug transporters may have clinical consequences and jeopardize development of promising drug candidates. Organic anion transporting polypeptides (OATP/Oatp) and the organic cation transporters (OCT/Oct) are among the most important transporters involved in xenobiotic uptake in the

Effectiveness of amiodarone versus bepridil in achieving conversion to sinus rhythm in patients with persistent atrial fibrillation: a randomised trial.

Miki Yamase et al.

Heart (British Cardiac Society), 98(14), 1067-1071 (2012-06-13)

Pharmacological conversion to sinus rhythm is generally difficult to achieve, particularly in long-lasting persistent atrial fibrillation (AF). The purpose of this study is to compare the effectiveness of two agents, amiodarone and bepridil, in achieving conversion to sinus rhythm in

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Bepridil -hydrochlorid