The product does not undergo testing to determine its suitability for use in cell culture applications. There is no data available characterizing its possible endotoxin concentration.
180947
Alginic acid sodium salt
powder
Synonym(s):
Algin, Sodium alginate
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100 G
HUF 24,100.00
250 G
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500 G
HUF 87,200.00
About This Item
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Product Name
Alginic acid sodium salt, powder
SMILES string
[Na+].[O-]C(=O)C1O[C@H]([C@H]([C@H]([C@@H]1O)O)O)O
InChI
1S/C6H10O7.Na/c7-1-2(8)4(5(10)11)13-6(12)3(1)9;/h1-4,6-9,12H,(H,10,11);/q;+1/p-1/t1-,2-,3-,4?,6+;/m0./s1
InChI key
MSXHSNHNTORCAW-MPGIDXPLSA-M
biological source
algae (marine)
form
powder
viscosity
15-25 cP, 1 % in H2O
Quality Level
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Related Categories
1 of 4
This Item | W201502 | PHR1471 | A2033 |
|---|---|---|---|
| biological source algae (marine) | biological source synthetic | biological source - | biological source algae (brown) |
| Quality Level 200 | Quality Level 400 | Quality Level 300 | Quality Level 200 |
| form powder | form - | form - | form powder |
| viscosity 15-25 cP, 1 % in H2O | viscosity - | viscosity - | viscosity ≥2,000 cP, 2 %(25 °C) |
Application
Alginic acid sodium is used:
- in combination with chitosan, to fabricate a biodegradable porous scaffold for bone tissue engineering.[1]
- to study the characteristics of a modified amphiphilic alginate derivative[2]
- to the study the impact of alginate on the rate of lipid digestion by employing an in vitro digestion model[3]
- in the preparation of alginate hydrogels[4]
- as encapsulating agents of microparticles of β-galactosidae[5]
General description
Alginic acid sodium is a gelling and nontoxic anionic polysaccharide. The carboxylic acid groups on the alginic acid chain, renders it insoluble in water.However, converting alginic acid to its sodium form, enables it to solubilize in water easily.[6]
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Zhensheng Li et al.
Biomaterials, 26(18), 3919-3928 (2005-01-01)
A biodegradable scaffold in tissue engineering serves as a temporary skeleton to accommodate and stimulate new tissue growth. Here we report on the development of a biodegradable porous scaffold made from naturally derived chitosan and alginate polymers with significantly improved
Role of calcium and calcium-binding agents on the lipase digestibility of emulsified lipids using an in vitro digestion model
Hu M, et al.
Food Hydrocolloids, 24(8), 719-725 (2010)
Thao Thi Thu Vu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 100(7), 1980-1988 (2012-08-14)
Alginate hydrogels possess tunable mechanical properties that can mimic soft marrow tissue and present three-dimensional (3D) cues. This study evaluates its utility for supporting leukemic cell growth in vitro and its impact on cell survival, growth, and differentiation. Our results
Microencapsulation of ?-galactosidase with different biopolymers by a spray-drying process
Estevinho BN, et al.
Food Research International, 64, 134-140 (2014)
Teegarden DM
Polymer Chemistry: Introduction to an Indispensable Science (2004)
Articles
Chitosan is a naturally occurring polysaccharide ideally suited for use in medical supplies, devices, therapeutics, and diagnostics. The unique natural characteristics of chitosan include its cationic, biocompatible, biodegradable, non-toxic, non-immunogenic, and antimicrobial properties.
Hydrogel-based biomaterials for cell delivery and tissue regeneration applications are discussed.
Collagen molecules play a critical role in tissue architecture and strength, and in cell-matrix interactions as insoluble ligands to regulate the diverse phenotypic activities of cells.
Discover hydrogels, biocompatible materials for drug delivery, tissue engineering, wound care, and 3D bioprinting in innovative biomedical applications
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Is there any toxicity when using this product for cell culture? Also, is there any information on endotoxin concentration?
1 answer-
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What is the molecular weight (average) of this product?
1 answer-
This product is considered a low viscosity Alginate with a published molecular weight range of 12,000 - 80,000 daltons.
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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Kindly let me know the solubility and PKa Values of Alginic acid sodium salt (180947-100G)
1 answer-
This product is assessed for pH and viscosity at 1% in deionized water indicating it is water soluble. The pKa of alginates is generally around 3.2–4.4 based upon details from literature. These details will need to be verified by the end user.
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Is the solution made with this at a 1-3 % W/V stable if sterilely filtered and frozen or at a certain temperature does it precipitate? How long would a solution last after preparation at 4 degrees or -20 degrees or -80 degrees? No crosslinking as of yet.
1 answer-
Unfortunately, no solution stability info is available for this product. The empirical result indicates that the lower w/v %, the less possibility for precipitation. The stock solution may remain stable at 4 Degrees. Storage at -20 or -80 Degrees is not recommended since phase separation may occur that reduces the stability of the solution.
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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what is the G/M ratio of this product? is G/M>1?
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Generally, the G/M ratio is not tested. The approximate amounts are 61% M and 39% G, resulting in an M/G ratio of 1.56. However, since this is not tested for each batch, the value cannot be guaranteed and should be treated as an approximation.
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What is the species name of the seaweed from which Product No. 180947 originates?
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This product is purified from Phaeophyceae or Brown Algae.
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What is the density of alginic acid sodium salt powder 180947
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Unfortunately, the density is not determined for this product.
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WHAT IS THE PURITY OF THE PRODUCT NO. 180947, ALGINIC ACID SODIUM SALT?
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The purity is not analyzed on a lot-to-lot basis. This product is a mixture, not a simple compound. The ratio of mannuronic acid to guluronic acid (M/G ratio) is 1.56.
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