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Merck

A2324

Amikacin sulfate salt

aminoglycoside antibiotic

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5 G

HUF 199,000.00

HUF 199,000.00

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About This Item

CAS Number:
149022-22-0
MDL number:
MFCD00167477
UNSPSC Code:
41116107
PubChem Substance ID:
24890648
NACRES:
NA.85

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biological source

synthetic

Quality Level

200

form

powder

concentration

691-806 μg/mg (dry)

color

white to off-white

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.NCC[C@@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O

InChI

1S/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8+,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1

InChI key

HIBICIOPDUTNRR-BOEHXBESSA-N

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1 of 4

This Item
A1774A3650B5264
Amikacin sulfate salt aminoglycoside antibiotic

Sigma-Aldrich

A2324

Amikacin sulfate salt

Amikacin disulfate salt potency: 674-786 μg per mg (as amikacin base)

Sigma-Aldrich

A1774

Amikacin disulfate salt

Amikacin hydrate aminoglycoside antibiotic

Sigma-Aldrich

A3650

Amikacin hydrate

Kanamycin B sulfate salt aminoglycoside antibiotic

Sigma-Aldrich

B5264

Kanamycin B sulfate salt

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

antibiotic activity spectrum

Gram-negative bacteria, mycobacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, mycobacteria

antibiotic activity spectrum

Gram-negative bacteria, mycobacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder or crystals

form

powder

form

powder or crystals

concentration

691-806 μg/mg (dry)

concentration

-

concentration

-

concentration

-

biological source

synthetic

biological source

synthetic

biological source

synthetic

biological source

-

General description

Chemical structure: aminoglycoside

Application

Amikacin is an aminoglycoside antibiotic commonly used in the treatment of drug-resistant mycobacteria [1]. It is used to study organism-directed delivery of antibiotics as well as drug resistance [2].

Biochem/physiol Actions

Amikacin prevents bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading.
Antibacterial spectrum: Gram-negative and gram-positive bacteria.

Analysis Note

Amikacin:Sulfate ratio 1:1.8

Other Notes

Aminoglycoside antibiotic. Derivative of kanamycin.
Keep container tightly closed in a dry and well-ventilated place.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000487996
0000487996
0000461578
0000461578
0000432175

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Targeted Delivery of Amikacin into Granuloma.
Ana Montes-Worboys, et al.
American Journal of Respiratory Cell and Molecular Biology, 182, 1546-1553 (2010)
Justin R Lenhard et al.
Diagnostic microbiology and infectious disease, 98(1), 115080-115080 (2020-07-04)
The objective of this study was to utilize a co-culture hollow-fiber infection model (HFIM) to characterize the interplay between a small, difficult-to-detect, New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae (NDM-Kp) minor population and a larger K. pneumoniae carbapenemase (KPC)-producing K. pneumoniae population
A M Lovering et al.
The Journal of antimicrobial chemotherapy, 43(5), 719-721 (1999-06-26)
Antibiotic-free human serum was spiked with known concentrations of liposomal amikacin and assayed on the Abbott TDx System, using polarization fluoroimmuno assay (PFIA) kits from Abbott Laboratories, Oxis and Sigma. Although all three kits gave a linear response, the Abbott
Luiz Fernando Feres et al.
Animal reproduction science, 193, 165-170 (2018-04-22)
The aim of the present study was to evaluate the likelihood of pregnancy of in vitro-produced (IVP) embryos from batches with distinct relative efficiencies. Data were retrospectively analyzed from 605 transvaginal ultrasonic-guided follicle aspiration sessions (OPU) followed by in vitro
Lejla Imamovic et al.
Cell, 172(1-2), 121-134 (2018-01-09)
Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These states are associated
View All Related Papers

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