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Merck

A6969

L-Arginine monohydrochloride

98.5-101.0%, suitable for cell culture, not synthetic, meets EP, JP, USP testing specifications

Synonym(s):

(S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride

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25 G

HUF 12,300.00

100 G

HUF 38,300.00

1 KG

HUF 189,000.00

HUF 12,300.00


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About This Item

Empirical Formula (Hill Notation):
C6H14N4O2 · HCl
CAS Number:
Molecular Weight:
210.66
Beilstein:
3631658
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

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Product Name

L-Arginine monohydrochloride, not synthetic, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%

Agency

USP/NF
meets EP testing specifications
meets JP testing specifications
meets USP testing specifications

Assay

98.5-101.0%

form

powder

optical activity

[α]20/D 22.1 to 22.9°, c = 8 in 6 M HCl

quality

meets EP, JP, USP testing specifications

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

226-230 °C

solubility

water: 100 mg/mL, clear, colorless

density

1.42 g/cm3 at 20 °C

anion traces

chloride (Cl-): 16.58-17.00%
sulfate (SO42-): ≤0.020%

cation traces

As: ≤1 ppm
Fe: ≤10 ppm
NH4+: ≤0.02%
heavy metals: ≤10 ppm

application(s)

pharmaceutical (small molecule)

functional group

(Guanidine)
amine
carboxylic acid

storage temp.

room temp

SMILES string

Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1

InChI key

KWTQSFXGGICVPE-WCCKRBBISA-N

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1 of 4

This Item
PHR145490538A4599
form

powder

form

-

form

-

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

cell culture | mammalian: suitable

functional group

(Guanidine), carboxylic acid, amine

functional group

-

functional group

-

functional group

-

assay

98.5-101.0%

assay

-

assay

-

assay

≥98.5%

storage temp.

room temp

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

-

cation traces

As: ≤1 ppm, NH4+: ≤0.02%, Fe: ≤10 ppm, heavy metals: ≤10 ppm

cation traces

-

cation traces

-

cation traces

As: ≤1.0 ppm, NH4+: ≤0.02%, heavy metals: ≤10 ppm

General description

L-arginine monohydrochloride is the hydrochloride salt form of L-arginine, an essential amino acid that plays a crucial role in several biological processes. It is commonly used in biology and biochemistry research as a cell culture supplement to support the growth and maintenance of various cell types.

Application

L-Arginine monohydrochloride has been used in mouse pancreas perfusion experiments.[1] It has also been used as a component of SILAC medium.[2]

Biochem/physiol Actions

L-Arginine is a dibasic, semi-essential amino acid. It acts as a precursor for creatinine and is a natural constituent of most of the dietary proteins.[3]
Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Features and Benefits

  • Suitable for Cell Culture and Biochemical research
  • High-quality compound suitable for multiple research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Nina C Hubner et al.
Methods (San Diego, Calif.), 53(4), 453-459 (2010-12-28)
Large-scale proteomic screens are increasingly employed for placing genes into specific pathways. Therefore generic methods providing a physiological context for protein-protein interaction studies are of great interest. In recent years many protein-protein interactions have been determined by affinity purification followed
Lorenzo Galluzzi K
Cell-wide Metabolic Alterations Associated with Malignancy (2014)
The role of somatostatin in GLP-1-induced inhibition of glucagon secretion in mice
Anne Orgaard
Diabetologia, 60(9), 1731-1739 (2017)
Élie Lambert et al.
Molecular & cellular proteomics : MCP, 19(5), 808-827 (2020-03-04)
HNF4α is a nuclear receptor produced as 12 isoforms from two promoters by alternative splicing. To characterize the transcriptional capacities of all 12 HNF4α isoforms, stable lines expressing each isoform were generated. The entire transcriptome associated with each isoform was
J. P. Felix D'Mello
Amino Acids in Human Nutrition and Health (2012)

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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