Skip to Content
Merck

C2920

Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone

≥98% (HPLC), powder, Mitophagy inducer

Synonym(s):

FCCP, Mesoxalonitrile 4-trifluoromethoxyphenylhydrazone

Slide 1 of 2
Sign In to View Organizational & Contract Pricing.

Select a Size

10 MG

HUF 63,100.00

50 MG

HUF 190,000.00

HUF 63,100.00

Please contact Customer Service for Availability
Request a Bulk Order

About This Item

Linear Formula:
CF3OC6H4NHN=C(CN)2
CAS Number:
370-86-5
Molecular Weight:
254.17
NACRES:
NA.77
PubChem Substance ID:
24892549
UNSPSC Code:
12352200
EC Number:
206-730-8
MDL number:
MFCD00009699
Beilstein/REAXYS Number:
664446

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone, ≥98% (HPLC), powder

InChI key

BMZRVOVNUMQTIN-UHFFFAOYSA-N

InChI

1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H

SMILES string

FC(F)(F)Oc1ccc(N\N=C(/C#N)C#N)cc1

assay

≥98% (HPLC)

form

powder

color

yellow

mp

174-175 °C (dec.) (lit.)

solubility

95% ethanol: soluble

storage temp.

2-8°C

Quality Level

300

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
C2759C2020N7634
Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone ≥98% (HPLC), powder

Sigma-Aldrich

C2920

Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone

Carbonyl cyanide 3-chlorophenylhydrazone ≥97% (TLC), powder

Sigma-Aldrich

C2759

Carbonyl cyanide 3-chlorophenylhydrazone

α-Cyano-4-hydroxycinnamic acid ≥98% (TLC), powder

Sigma-Aldrich

C2020

α-Cyano-4-hydroxycinnamic acid

Nifedipine ≥98% (HPLC), powder

Sigma-Aldrich

N7634

Nifedipine

assay

≥98% (TLC)

assay

≥97% (TLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

300

Quality Level

200

Quality Level

300

Quality Level

200

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

95% ethanol: soluble

solubility

DMSO: 100 mM

solubility

H2O: slightly soluble, methanol: water: soluble, polar organic solvents: soluble

solubility

DMSO: soluble, ethanol: soluble

color

yellow

color

yellow to orange

color

yellow

color

yellow

Application

Carbonylcyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) has been used as an uncouplerin cell culture: to study its effects on murine thermogenic adipocytes[1], tostudy its effects on β-oxidation in mouse mitochondria[2], to study its effects on the metabolism in bone marrow-derived dendriticcells from mouse[3]

General description

FCCP is a protonophore (H+ ionophore) and uncoupler of oxidative phosphorylation in mitochondria.[4] It is capable of depolarizing plasma and mitochondrial membranes. FCCP has been shown to have several effects on cellular calcium. It is also reported to inhibit a background K+ current and induce a small inward current, reduce pH by 0.1 unit, and induce a rise of intracellular [Na+]. FCCP stimulates Mg2+-ATPase activity, inhibits β-amyloid production, and mimics the effect of selective glutamate agonist N-methyl-D-aspartate (NMDA) on mitochondrial superoxide production.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000436114
0000436114
0000409669
0000409669
0000374029

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Isa Mambetsariev et al.
Journal of clinical medicine, 8(7) (2019-07-19)
Small cell lung cancer (SCLC) is an aggressive neuroendocrine disease with an overall 5 year survival rate of ~7%. Although patients tend to respond initially to therapy, therapy-resistant disease inevitably emerges. Unfortunately, there are no validated biomarkers for early-stage SCLC
Kyu-Sang Park et al.
Pflugers Archiv : European journal of physiology, 443(3), 344-352 (2002-01-26)
We investigated the effects of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP), a protonophore and uncoupler of mitochondrial oxidative phosphorylation in mitochondria, on plasma membrane potential and ionic currents in bovine aortic endothelial cells (BAECs). The membrane potential and ionic currents of BAECs were
Aleksandar Rakovic et al.
Cell death and differentiation, 26(8), 1428-1441 (2018-10-31)
The Parkinson's disease (PD)-related ubiquitin ligase Parkin and mitochondrial kinase PINK1 function together in the clearance of damaged mitochondria. Upon mitochondrial depolarization, Parkin translocates to mitochondria in a PINK1-dependent manner to ubiquitinate outer mitochondrial membrane proteins. According to the current
Sunjin Lee et al.
Ecotoxicology and environmental safety, 182, 109377-109377 (2019-06-30)
The measurement of oxygen consumption rate (OCR) provides a comprehensive understanding of mitochondrial metabolism. However, no study has been conducted to investigate the mitochondrial dysfunction caused by organophosphate flame retardants (OPFRs). The objectives of this study were to optimize the
Lisa Kappler et al.
American journal of physiology. Endocrinology and metabolism, 317(2), E374-E387 (2019-06-19)
Mitochondria are dynamic organelles with diverse functions in tissues such as liver and skeletal muscle. To unravel the mitochondrial contribution to tissue-specific physiology, we performed a systematic comparison of the mitochondrial proteome and lipidome of mice and assessed the consequences
View All Related Papers

Articles

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service