C8895

Clofazimine

≥98% (TLC), powder, antimycobacterial rimonphenazine

• Synonym(s): N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
• Empirical Formula (Hill Notation): C₂₇H₂₂Cl₂N₄
• CAS Number: 2030-63-9
• Molecular Weight: 473.40
• NACRES: NA.77
• PubChem Substance ID: 24893114
• UNSPSC Code: 12352200
• EC Number: 217-980-2
• MDL number: MFCD00056793

Properties

• Product Name: Clofazimine,
• form: powder
• InChI key: WDQPAMHFFCXSNU-BGABXYSRSA-N
• InChI: 1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+
• SMILES string: CC(C)\N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5
• antibiotic activity spectrum: mycobacteria
• mode of action: protein synthesis | interferes
• originator: Novartis
• Quality Level: 200

Description

Application

Clofazimine has been used:

• for antimicrobial preparation[1]
• to study its accumulation on macrophages to form crystal-like drug inclusions (CLDIs)[2][3][4]
• to model drug-induced hepatic granulomatous inflammation[5]
• to study the in vivo cargo storage capacity of macrophages[6]

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis.[7] Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus.[8] Clofazimine has immunosuppressive property.[9]

Preparation Note

This product is stored at room temperature.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves