G5668

GW1929 hydrate

Name: GW1929 hydrate
Brand: SIGMA
Price: 73300 HUF

>98% (HPLC), solid

Synonym(s):

N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrate

Slide 1 of 1

Select a Size

5 MG

HUF 73,300.00

25 MG

HUF 296,000.00

HUF 73,300.00

Please contact Customer Service for Availability

Request a Bulk Order

About This Item

Empirical Formula (Hill Notation):

C₃₀H₂₉N₃O₄ · xH₂O

CAS Number:

1049740-86-4

Molecular Weight:

495.57 (anhydrous basis)

MDL number:

MFCD11045925

UNSPSC Code:

12352200

PubChem Substance ID:

24278789

NACRES:

NA.77

Key Documents

View All Documentation

Assay

>98% (HPLC)

form

solid

solubility

DMSO: 20 mg/mL

originator

GlaxoSmithKline

SMILES string

[H]O[H].CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c3ccccc3)C(O)=O)cc1)c4ccccn4

InChI

1S/C30H29N3O4.H2O/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23;/h2-18,27,32H,19-21H2,1H3,(H,35,36);1H2/t27-;/m0./s1

InChI key

XSITZVFUXCLFMK-YCBFMBTMSA-N

Gene Information

human ... PPARG(5468)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	R2408	M2199	U111
Sigma-Aldrich G5668 GW1929 hydrate	Sigma-Aldrich R2408 Rosiglitazone	Sigma-Aldrich M2199 PMEG hydrate	Sigma-Aldrich U111 (−)-trans-(1S,2S)-U-50488 hydrochloride hydrate
assay >98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form powder	form powder	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility DMSO: 20 mg/mL	solubility DMSO: ≥10 mg/mL	solubility DMSO: ≥5 mg/mL	solubility H₂O: 13 mg/mL
originator GlaxoSmithKline	originator GlaxoSmithKline	originator -	originator -
Gene Information human ... PPARG(5468)	Gene Information human ... PPARG(5468)	Gene Information -	Gene Information human ... OPRK1(4986)

Application

GW1929 has been used as a peroxisome proliferator-activated receptor γ (PPARγ) ligand:

to study its effects on plant homeodomain finger protein 16 (Phf16) and patatin-like phospholipase domain containing 3 (Pnpla3) expression involved in adipogenesis[1]
to study its effects on complement component 3 (C3) gene expression in human hepatoma cells[2]
to activate PPARγ in human breast cancer cells[3]

Biochem/physiol Actions

GW1929 is a high affinity agonist of PPAR-γ.

GW1929 is a non-thiazolidinedione and is involved in cell growth inhibition and regulating gene expression.[4] It exhibits neuroprotective effects against global cerebral ischemic-reperfusion injury by DNA fragmentation and minimizing the inflammation.[5] GW1929 participates in the inhibition of α7 N-acetylcholine receptor expression and promoter activity. It also influences the early growth response-1 (Egr-1) protein expression.[4]

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes only, pursuant to an agreement with GlaxoSmithKline

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Identification of Phf16 and Pnpla3 as new adipogenic factors regulated by phytochemicals.

Seo-Hyuk Chang et al.

Journal of cellular biochemistry, 120(3), 3599-3610 (2018-10-03)

Adipocyte differentiation is controlled by multiple signaling pathways. To identify new adipogenic factors, C3H10T1/2 adipocytes were treated with previously known antiadipogenic phytochemicals (resveratrol, butein, sulfuretin, and fisetin) for 24 hours. Commonly regulated genes were then identified by transcriptional profiling analysis. Three

GW1929 inhibits α7 nAChR expression through PPARγ-independent activation of p38 MAPK and inactivation of PI3-K/mTOR: The role of Egr-1.

Swei Sunny Hahn et al.

Cellular signalling, 26(4), 730-739 (2014-01-15)

Studies demonstrated that peroxisome proliferator-activated receptor gamma (PPARγ) ligands reduce nicotine-induced non small cell lung carcinoma (NSCLC) cell growth through inhibition of nicotinic acetylcholine receptor (nAChR) mediated signaling pathways. However, the mechanisms by which PPARγ ligands inhibited nAChR expression remain

GW1929: a nonthiazolidinedione PPARγ agonist, ameliorates neurological damage in global cerebral ischemic-reperfusion injury through reduction in inflammation and DNA fragmentation.

Ravinder K Kaundal et al.

Behavioural brain research, 216(2), 606-612 (2010-09-14)

Transient global cerebral ischemia results in acute neurodegeneration in selective brain areas. Global cerebral ischemic-reperfusion (IR) injury induced selective hippocampal damage results into various neurobehavioral deficits including spatial memory and learning deficiencies. In this study, we have investigated the protective

PPARγ modulates refractive development and form deprivation myopia in Guinea pigs.

Miaozhen Pan et al.

Experimental eye research, 202, 108332-108332 (2020-11-06)

Form deprivation myopia (FDM) is characterized by loss of choroidal thickness (ChT), reduced choroidal blood perfusion (ChBP), and consequently scleral hypoxia. In some tissues, changes in levels of peroxisome proliferator-activated receptor γ (PPARγ) expression modulate hypoxia-induced pathological responses. We determined

Insulin downregulates C3 gene expression in human HepG2 cells through activation of PPARγ.

Vladimir S Shavva et al.

European journal of cell biology, 97(3), 204-215 (2018-03-20)

C3 is an acute phase protein, and thus its plasma concentration increases quickly and drastically during the onset of inflammation. Insulin plays a complex role in inflammation. Elevated level of plasma C3 was shown to correlate with heightened fasting insulin

View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

GW1929 hydrate