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P4562

Sodium pyruvate

powder, BioXtra, suitable for mouse embryo cell culture

Synonym(s):

α-Ketopropionic acid sodium salt, 2-Oxopropanoic acid sodium salt, Pyruvic acid sodium salt

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About This Item

Linear Formula:
CH3COCOONa
CAS Number:
113-24-6
Molecular Weight:
110.04
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
24898552
EC Number:
204-024-4
Beilstein/REAXYS Number:
3568341
MDL number:
MFCD00002586

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Product Name

Sodium pyruvate, powder, BioXtra, suitable for mouse embryo cell culture

InChI key

DAEPDZWVDSPTHF-UHFFFAOYSA-M

InChI

1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1

SMILES string

[Na+].CC(=O)C([O-])=O

product line

BioXtra

assay

≥99%

form

powder

technique(s)

cell culture | embryo: suitable

mp

>300 °C (lit.)

solubility

H2O: 100 mg/mL

storage temp.

2-8°C

Quality Level

200

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1 of 4

This Item
PHR9297792500105477
Sodium pyruvate powder, BioXtra, suitable for mouse embryo cell culture

Sigma-Aldrich

P4562

Sodium pyruvate

Sodium pyruvate certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

PHR9297

Sodium pyruvate

Sodium pyruvate anhydrous, free-flowing, Redi-Dri™, ReagentPlus®, ≥99%

Sigma-Aldrich

792500

Sodium pyruvate

Sodium pyruvate EMPROVE® EXPERT

SAFC

105477

Sodium pyruvate

assay

≥99%

assay

-

assay

≥99%

assay

-

solubility

H2O: 100 mg/mL

solubility

-

solubility

H2O: 100 mg/mL, clear, colorless to faintly yellow

solubility

-

Quality Level

200

Quality Level

300

Quality Level

100

Quality Level

500

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

form

powder

form

-

form

powder

form

solid

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

>300 °C (lit.)

Application

Sodium pyruvate has been used:
  • as a supplement in Ca2+ + N-Tris(hydroxymethil)methyl-2-aminoethanesulfonic acid (TES)–NaCl medium for sperm incubation[1]
  • as a supplement in TCM-199 hepes modification solution for cumulus-oocytes complexes (COC′s) culture[2]
  • as a supplement in Dulbecco′s modified Eagle medium (DMEM) to culture mouse primary hepatocytes (MPHs) and also to intraperitoneally inject fasted mice for glucose production assessment[3]

Biochem/physiol Actions

Sodium pyruvate is mainly used as a constituent in culture broth and media. It exhibits anti-oxidation and anti-inflammatory properties. Hence sodium pyruvate is considered a possible therapy for allergic rhinitis.[4] Sodium pyruvate might also be a new approach treating lactic acidosis.[5]
Sodium pyruvate is used by cells as an easily accessible carbohydrate source. Additionally, it is involved with amino acid metabolism and initiates the Kreb′s cycle. Sodium pyruvate attenuates oxidative stress in vitro. The 100 mM solution should be diluted at 1:100 for most cell culture applications. This product has been qualified for use in mouse embryo cultures.

General description

Pyruvate, the end-product of the glycolysis pathway,[6] is the anion of pyruvic acid.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317,H319

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1B

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000512953
0000512953
0000500374
0000500374
0000495061

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Jing Yang et al.
Artificial cells, nanomedicine, and biotechnology, 44(1), 48-55 (2014-04-05)
To examine the effects of sodium pyruvate (SP) on metabolic acidosis. For the in vivo experiments, we evaluated effects of SP on an ammonium chloride (NH4Cl)-induced hyperchloremic acidosis rat model. SP was infused at overall doses of 2, 4, and
Rangga Setiawan et al.
Animal reproduction science, 233, 106843-106843 (2021-09-15)
Adenosine triphosphate (ATP) production via glycolysis and oxidative phosphorylation is essential for the maintenance of flagellar motility in sperm; however, the primary energy production pathways supporting fertilization vary among species. Inconsistency in thought exists regarding which pathways maintain ATP production
Maheul Ploton et al.
Journal of hepatology, 69(5), 1099-1109 (2018-07-08)
Embedded into a complex signaling network that coordinates glucose uptake, usage and production, the nuclear bile acid receptor FXR is expressed in several glucose-processing organs including the liver. Hepatic gluconeogenesis is controlled through allosteric regulation of gluconeogenic enzymes and by
In vitro maturation of caprine oocytes in different concentrations of estrous goat serum
Kharche SD, et al.
Small Ruminant Research (2006)
L S Li et al.
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 31(2), 103-106 (2017-01-20)
Objective:Pyruvate is a key intermediate in several metabolic pathways of human body Sodium pyruvate possesses anti-oxidation and anti-inflammatory effects, which make it a possible novel therapy for allergic rhinitis. However, the relevant clinical research is rare. The aim of the
View All Related Papers

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Product Information Sheet - P4562

Product Information Sheet

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