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166314K

Collagen Mimetic peptides MAPTRIX-C-TAIPSCPEGTVPLYS

Name: Collagen Mimetic peptides MAPTRIX-C-TAIPSCPEGTVPLYS
Brand: SIGMA

animal-free ECM peptides, solution, 1.0 mg/mL protein, suitable for cell culture

別名:

MAPTrix^™ Technology

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この商品について

UNSPSC Code:

12352202

NACRES:

NA.75

Form:

aqueous solution

Technique(s):

cell culture | mammalian: suitable

Concentration:

1.0 mg/mL protein

Mol wt:

~24.1 kDa

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特性

製品名

MAPTRIX-C-TAIPSCPEGTVPLYS, Collagen Mimetic, aqueous solution

sterility

Filtered sterilized solution

form

aqueous solution

mol wt

~24.1 kDa

packaging

pkg of 10 mg

concentration

1.0 mg/mL protein

technique(s)

cell culture | mammalian: suitable

binding specificity

Domain: α3(IV) NC1
Binding Motif: TAIPSCPEGTVPLYS

shipped in

ambient

storage temp.

2-8°C

詳細

Application

MAPTrix^™ Technology provides a true extracellular microenvironment (ECM) by presenting combinatorial peptide motifs. The ECM, defined by biochemical cues and physical cues, is a deciding factor in a wide range of cellular processes including cell adhesion, proliferation, differentiation, and expression of phenotype-specific functions.Currently existing technology offers simple and merely adequate environments that facilitate simple cell processes such as cellular adhesion.[1][2] The simple presentation of cell adhesion motifs is not optimal for controlling more integrated processes. Crosstalk among signaling pathways act synergistically to enhance cellular responses such as cell adhesion or proliferation.[3] A study showed that a combination of extracellular matrix derived peptides presented on a surface may enhance cell adhesion strength and focal adhesion assembly. The combinatorial presentation of ECM peptides on cell growth surfaces may also promote elevated proliferation rates of primary or stem cells.[4][5][6]

Features and Benefits

Biochemically-defined, animal-free cell culture surfaces designed to enhance cell performance
MAPTrix^™ produces a uniform ECM surface that provides a highly controlled 2D extracellular microenvironment for cell cultures and related applications
Adhesion properties of the mussel adhesive protein makes the coating reproducible & reliable

Legal Information

MAPTrix is a trademark of Kollodis Biosciences

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当該品目	162294K	162324K	164144K
Sigma-Aldrich 166314K MAPTRIX-C-TAIPSCPEGTVPLYS	Sigma-Aldrich 162294K MAPTRIX-L-TWYKIAFQRNRK	Sigma-Aldrich 162324K MAPTRIX-L-RKRLQVQLSIRT	Sigma-Aldrich 164144K MAPTRIX-L-YIGSR
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
sterility Filtered sterilized solution	sterility Filtered sterilized solution	sterility Filtered sterilized solution	sterility Filtered sterilized solution
concentration 1.0 mg/mL protein	concentration 1.0 mg/mL protein	concentration 1.0 mg/mL protein	concentration 1.0 mg/mL protein
form aqueous solution	form aqueous solution	form aqueous solution	form aqueous solution
mol wt ~24.1 kDa	mol wt ~24.2 kDa	mol wt ~24.1 kDa	mol wt ~23.1 kDa
packaging pkg of 10 mg	packaging pkg of 10 mg	packaging pkg of 10 mg	packaging pkg of 10 mg

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保管分類

12 - Non Combustible Liquids

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

166314K-10MG:

jan

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Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms.

Samuel Schmidt et al.

Cell and tissue research, 339(1), 83-92 (2009-11-19)

Adhesion and migration are integrated cell functions that build, maintain and remodel the multicellular organism. In migrating cells, integrins are the main transmembrane receptors that provide dynamic interactions between extracellular ligands and actin cytoskeleton and signalling machineries. In parallel to

Engineering integrin signaling for promoting embryonic stem cell self-renewal in a precisely defined niche.

Seung Tae Lee et al.

Biomaterials, 31(6), 1219-1226 (2009-11-21)

We present development and use of a 3D synthetic extracellular matrix (ECM) analog with integrin-specific adhesion ligands to characterize the microenvironmental influences in embryonic stem cell (ESC) self-renewal. Transcriptional analysis of 24 integrin subunits followed by confirmation at the translational

Integrin-mediated adhesion and stem-cell-niche interactions.

Stephanie J Ellis et al.

Cell and tissue research, 339(1), 121-130 (2009-07-10)

The regulation of stem cell behavior and maintenance typically involves the integration of both intrinsic and extrinsic cues. One such external cue, integrin-mediated cell adhesion to the extracellular matrix, plays an important part in regulating stem cell function and maintenance.

グローバルトレードアイテム番号

カタログ番号	GTIN
166314K-10MG	04061838748904

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