A6402

[Asn¹, Val⁵]-アンジオテンシン II

≥97% (HPLC), angiotensin agonist, powder

• 実験式（ヒル表記法）: C₄₉H₇₀N₁₄O₁₁
• CAS番号: 20071-00-5
• 分子量: 1031.17
• UNSPSC Code: 12352209
• PubChem Substance ID: 329770893
• NACRES: NA.32
• MDL number: MFCD00167643
• Assay: ≥97% (HPLC)
• Form: powder

特性

• 製品名: [Asn¹, Val⁵]-アンジオテンシン II, ≥97% (HPLC)
• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: powder
• storage temp.: −20°C
• SMILES string: CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O
• InChI: 1S/C49H70N14O11/c1-26(2)39(61-42(67)33(12-8-18-55-49(52)53)57-41(66)32(50)23-38(51)65)45(70)58-34(20-29-14-16-31(64)17-15-29)43(68)62-40(27(3)4)46(71)59-35(22-30-24-54-25-56-30)47(72)63-19-9-13-37(63)44(69)60-36(48(73)74)21-28-10-6-5-7-11-28/h5-7,10-11,14-17,24-27,32-37,39-40,64H,8-9,12-13,18-23,50H2,1-4H3,(H2,51,65)(H,54,56)(H,57,66)(H,58,70)(H,59,71)(H,60,69)(H,61,67)(H,62,68)(H,73,74)(H4,52,53,55)/t32-,33-,34-,35-,36-,37-,39-,40-/m0/s1
• InChI key: JYPVVOOBQVVUQV-CGHBYZBKSA-N
• Gene Information: human ... AGTR1(185) ; mouse ... AGTR1(11607) ; rat ... AGTR1(24180)

詳細

General description

Angiotensin II is a renin-angiotensin system (RAS) effector molecule, which binds to angiotensin II type-1 (AT₁R) and angiotensin II type-2 (AT₂R) receptors. The gene is located on human chromosome 3q24. Angiotensin II is mainly expressed in vessel walls, lung and kidney.

Application

[Asn¹, Val⁵]-Angiotensin II has been used:

• to study the effects of ACTH, serotonin, Ang II, carbachol and elevated [K⁺] on catecholamine and serotonin release
• to induce cyclophilin D (CypD)–dependent mitochondrial vascular superoxide (O2^{. -} ) production in hypertension
• to increase the homocysteine-induced ER stress-inducible, ubiquitin-like domain member 1 (HERPUD1) protein level in HeLa cells

Biochem/physiol Actions

Angiotensin II functions as a vasoconstrictor and controls cardiovascular function. It maintains water-sodium homeostasis, modulates cellular proliferation and vascular remodelling of renin-angiotensin system. Angiotensin II has inflammatory effects.

魚類の血圧調節、水分消費、ハイドロミネラルバランスに関与する合成アンジオテンシンアゴニストです。

安全性情報

• 保管分類: 11 - Combustible Solids
• WGK: WGK 3
• 引火点 (F): Not applicable
• 引火点（°C）: Not applicable