A6719

ω-アガトキシンIVA

≥90% (HPLC)

• 別名: SNX 290
• 実験式（ヒル表記法）: C₂₁₇H₃₆₀N₆₈O₆₀S₁₀
• CAS番号: 145017-83-0
• 分子量: 5202.25
• UNSPSC Code: 12352200
• NACRES: NA.28
• MDL number: MFCD00165055

特性

• Quality Segment: 200
• assay: ≥90% (HPLC)
• form: powder
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• Gene Information: human ... CACNA1A(773) ; mouse ... CACNA1A(12286) ; rat ... CACNA1A(25398)

詳細

General description

CACNA1A (calcium voltage-gated channel subunit alpha1 A) gene codes for the α1 subunit of neuronal CaV2.1 (P/Q-type) voltage-gated calcium channels. It is expressed throughout the central nervous system (CNS). CACNA1A gene is located on human chromosome 19p13.

Application

ω-Agatoxin IVA has been used in the manipulation of calcium influx. It has also been used in the study to characterize the spontaneous and evoked activity from murine ventral horn cultures on microelectrode arrays.

Biochem/physiol Actions

ジョウゴグモAgelenopsis apteraの毒液から発見された毒素です。哺乳類のP型電位依存性カルシウムチャネルの強力かつ選択的なブロッカ-です。

Mutations in the CACNA1A (calcium voltage-gated channel subunit alpha1 A) gene is responsible for episodic ataxia 2, familial hemiplegic migraine type 1 (FHM1) and spinocerebellar ataxia type 6 (SCA6).

Features and Benefits

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• 保管分類: 11 - Combustible Solids
• WGK: WGK 3
• 引火点 (F): Not applicable
• 引火点（°C）: Not applicable