B0806

抗BACE 1, C末端(485-501)抗体 ウサギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• 別名: 抗β-部位APP切断酵素抗体
• UNSPSC Code: 12352203
• NACRES: NA.43
• MDL number: MFCD03454775
• Conjugate: unconjugated
• Clone: polyclonal
• Application: ARR, WB
• Citations: 13

特性

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 70 kDa
• species reactivity: human
• enhanced validation: recombinant expression; Learn more about Antibody Enhanced Validation
• technique(s): microarray: suitable, western blot: 1:1,000 using a whole cell extract from the human kidney HEK293 cell line stably transfected with human BACE-1
• UniProt accession no.: P56817
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... BACE1(23621)

詳細

General description

BACE-1 (β-site APP cleaving enzyme, Asp2 or memapsin 2) is known as β-secretase. BACE-1 is highly expressed in neurons, the major site of Aβ generation. BACE-1 is localized within the Golgi and endosomal compartments, among the several intracellular sites where Aβ is thought to be produced. It constitutes the predominant β-secretase activity in human brain tissue.

Immunogen

ヒトBACE-1のC末端(アミノ酸 485-501)に相当する合成ペプチド。

Application

Anti-BACE 1, C-Terminus (485-501) antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Overexpression of β-site APP cleaving enzyme (BACE-1) leads to increased β-secretase activity while displaying appropriate cleavage site specificity for amyloid precursor protein (APP).

Physical form

0.01M PBS溶液 (pH 7.4, 1%BSA, 15mMアジ化ナトリウム含有)。

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類: 12 - Non Combustible Liquids
• 一体何が起きているの？: nwg
• 引火点 (F): Not applicable
• 引火点（°C）: Not applicable