C8243
モノクロナール抗カテプシンK マウス宿主抗体
~2 mg/mL, clone CL124-1H6, purified immunoglobulin, buffered aqueous solution
別名:
抗CTSK抗体, 抗CTSO2抗体, 抗PKND抗体, 抗PYCD抗体
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この商品について
Conjugate:
unconjugated
Clone:
CL124-1H6, monoclonal
Application:
ELISA (i), WB
Citations:
12
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
CL124-1H6, monoclonal
form
buffered aqueous solution
mol wt
antigen ~27 kDa
species reactivity
human
concentration
~2 mg/mL
technique(s)
indirect ELISA: suitable, western blot: 10-20 μg/mL using total cell extracts of HCT-116 cells
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CTSK(1513)
General description
Cathepsins are proteases that normally localized in lysosomes of almost all mammalian cells, but under certain conditions they can be secreted from the cell. Cathepsins are classified based on their functions and presence of active site such as cathepsin B, D, K, V, F etc.
Monoclonal Anti-Cathepsin K (mouse IgG2b isotype) is derived from the hybridoma CK124-1H6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with recombinant human cathepsin K.
Immunogen
組み換えヒトカテプシンK。エピト-プは、アミノ酸222~235に相当するペプチド配列RGYREIPEGNEKAL内に存在します。
Application
Monoclonal Anti-Cathepsin K antibody produced in mouse has been used in western blotting and enzyme linked immunosorbent assay (ELISA).
Biochem/physiol Actions
本抗体は、類似したリソソ-ムシステインプロテア-ゼであるカテプシンL、B、H、S、V、Wとは交差反応しません。
Cathepsin is involved in various functions such as intracellular degradation of exogenous and endogenous proteins, activation of enzyme precursors, and tumor invasion and metastasis. Among all the types, cathepsins K (Ctsk) is highly expressed in osteoclasts that plays a crucial role in bone remodeling and resorption. Cathepsin K protein was found in primary breast carcinoma and prostate cancer where it performs in the invasive process of prostate cancers, thyroid carcinoma, lung adenocarcinoma and breast carcinoma. Its deficency causes pycnodysostosis, a rare bone dysplasia with an osteopetrotic-like phenotype.
Physical form
15 mMアジ化ナトリウム含有のpH 7.4の0.01 Mリン酸緩衝食塩水溶液.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類
10 - Combustible liquids
WGK
WGK 2
引火点 (F)
Not applicable
引火点（°C）
Not applicable
PPE（個人用保護具）
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)