E101

S-(-)-エチクロプリド 塩酸塩

≥98% (HPLC), D2 dopamine receptor antagonist, powder

• 別名: FLB 131, S-(-)-3-クロロ-5-エチル-N-[(1-エチル-2-ピロリジニル)メチル]-6-ヒドロキシ-2-メトキシベンズアミド 塩酸塩
• 実験式（ヒル表記法）: C₁₇H₂₅ClN₂O₃ · HCl
• CAS番号: 97612-24-3
• 分子量: 377.31
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278428
• NACRES: NA.77
• MDL number: MFCD00055132
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

特性

• 製品名: S-(-)-エチクロプリド 塩酸塩, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]27/D −7.2°, c = 0.3 in methanol(lit.)
• storage condition: desiccated
• color: off-white
• solubility: H₂O: soluble >10 mg/mL, ethanol: soluble 2.6 mg/mL, 0.1 M HCl: soluble 7 mg/mL
• SMILES string: Cl.CCN1CCC[C@H]1CNC(=O)c2c(O)c(CC)cc(Cl)c2OC
• InChI: 1S/C17H25ClN2O3.ClH/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2;/h9,12,21H,4-8,10H2,1-3H3,(H,19,22);1H/t12-;/m0./s1
• InChI key: HFJFXXDHVWLIKX-YDALLXLXSA-N
• Gene Information: human ... DRD2(1813)

詳細

Application

S-(−)-Eticlopride hydrochloride has been used in astrocyte-neuron coculture and functional magnetic resonance imaging (fMRI) experiments.

Biochem/physiol Actions

Potent and selective D2 dopamine receptor antagonist. Eticlopride is highly specific for DAD2 receptors than pimozide or haloperidol. The gene encoding the D2 dopamine receptor (DRD2) is linked with a several disorders including Parkinson′s disease, schizophrenia, and susceptibility to alcoholism.

Preparation Note

溶液は4℃で数日間保存できます。

Legal Information

Astra ABの許可を得て製造販売を行っています。

安全性情報

• 保管分類: 11 - Combustible Solids
• 一体何が起きているの？: WGK 3
• 引火点 (F): Not applicable
• 引火点（°C）: Not applicable
• PPE（個人用保護具）: Eyeshields, Gloves, type N95 (US)