SML3003

AS3334034

≥98% (HPLC)

• 別名: 7-Methoxy-6-(2-methylpropane-2-sulfonyl)-N-(4-methyl-1H-pyrazol-3-yl)quinolin-4-amine
• 実験式（ヒル表記法）: C₁₈H₂₂N₄O₃S
• CAS番号: 2724942-14-5
• 分子量: 374.46
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

特性

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: CC1=CNN=C1NC2=CC=NC3=CC(OC)=C(S(=O)(C(C)(C)C)=O)C=C32
• InChI: 1S/C18H22N4O3S/c1-11-10-20-22-17(11)21-13-6-7-19-14-9-15(25-5)16(8-12(13)14)26(23,24)18(2,3)4/h6-10H,1-5H3,(H2,19,20,21,22)
• InChI key: WCPMUQAUSFXFJE-UHFFFAOYSA-N

詳細

Biochem/physiol Actions

AS3334034 is an orally available, potent and selective RIP2 (Receptor-interacting protein kinase 2) inhibitor that exhibits renoprotective effects in uninephrectomized adriamycin-induced CKD (chronic kidney disease) rats. It appears that AS3334034 suppresses the progression of chronic renal failure via an anti-inflammatory effect.

Orally available, potent and selective RIP2 inhibitor that exhibits renoprotective effects

安全性情報

• 保管分類: 11 - Combustible Solids
• 一体何が起きているの？: WGK 3
• 引火点 (F): Not applicable
• 引火点（°C）: Not applicable