Todas las fotos(2)

D4902

Sigma-Aldrich

Dexamethasone

powder, BioReagent, suitable for cell culture, ≥97%

Sinónimos:
9α-Fluoro-16α-methylprednisolone, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, Prednisolone F, (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Empirical Formula (Hill Notation):
C22H29FO5
Número de CAS:
Peso molecular:
392.46
Beilstein:
2066651
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.75

Nivel de calidad

200

origen biológico

synthetic

línea de producto

BioReagent

ensayo

≥97%

formulario

powder

potencia

4-500 ng/mL

aplicaciones

cell culture | mammalian: suitable

mp

262-264 °C (lit.)

solubilidad

methanol: 25 mg/mL

enviado en

ambient

temp. de almacenamiento

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

¿Está buscando productos similares? Visit Guía de comparación de productos

Categorías relacionadas

Aplicación

Dexamethasone is used to study apoptosis, cell signaling pathways, cell differentiation and gene expression.

Envase

25, 100, 500 mg in glass bottle
1 g in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.

Acciones bioquímicas o fisiológicas

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.
It is poorly metabolized in the body and has great affinity and bioavailability.

Forma física

powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstitución

To prepare 20 μg/ml stock solution, add 1ml absolute ethanol per mg product; gently swirl to dissolve. Add 49 ml sterile medium per ml of ethanol added, while mixing, to acheive final concentration of 20 μg/ml.

pictogramas

Health hazard

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Repr. 1B

Código de clase de almacenamiento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificado de Análisis

Certificado de origen

  1. What is Product D4902, Dexamethasone, soluble in?

    Dexamethasone is practically insoluble in water. It is soluble in ethanol, methanol, acetone, dioxane and slightly soluble in chloroform. 

  2. How should I reconstitute Product D4902, Dexamethasone, for tissue culture use?

    The tissue culture grade product is dissolved in ethanol at a concentration of 1 mg/ml forming a clear, colorless solution.  It is also possible to prepare a stock solution of dexamethasone in DMSO at 1.5 mM. 

  3. Do you have references for the use of Product D4902, Dexamethasone?

    References can be found on the product detail page:Migliorati, G., et al., Dexamethasone and interleukins modulate apoptosis of murine thymocytes and peripheral T-lymphocytes. Pharmacol Res., 30(1), 43-52 (1994).Bansal, N., et al., Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents. FASEB J. 5(2), 211-6 (1991).Shiao, R.T., et al., Dexamethasone and suramin inhibit cell proliferation and interleukin-6-mediated immunoglobulin secretion in human lymphoid and multiple myeloma cell lines. Leuk. Lymphoma, 17(5-6), 485-494 (1995).Migliorati, G., et al, Dexamethasone induces apoptosis in mouse natural killer cells and cytotoxic T lymphocytes. Immunology, 81(1), 21-26 (1994).

  4. How long is Product D4902, Dexamethasone, stable in solution?

    Dexamethasone solutions are stable for at least 30 days when stored at 4 °C and protected from light. The solution may be aliquoted and stored at -20 °C. However, insufficient information is available to assess the shelf-life of the frozen solution.

  5. What cell lines has Product D4902, Dexamethasone, been tested on?

    The cell lines on which this product is tested can vary from lot to lot. Some typically used cell lines are 3T3 fibroblasts, BHK, L929 and CHO.

  6. What is the shelf life of Product D4902, Dexamethasone?

    The product has a 5 year shelf life.

  7. Product D4902, Dexamethasone is not water soluble. Do you have a water soluble Dexamethasone?

    Product D2915 is water soluble.

  8. Can I use Product D4902, Dexamethasone, to inject into mice?

    We do not perform animal studies with our products, but it can be used in cell culture (D2915 - cell culture grade version, or USP grade product D9184).

  9. Are Products D4902 and D2915, sterile?

    No. This product is not sterile, but cell culture testing did not find the product to be toxic to cells.

  10. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  11. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  12. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  13. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  14. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Recapitulation of metabolic defects in a model of propionic acidemia using patient-derived primary hepatocytes
Kimberly A Chapman
Molecular Genetics and Metabolism, 117, 355-362 (2016)
Isolation of Mesenchymal Stem Cells from Human Deciduous Teeth Pulp.
Tsai Aileen
BioMed Research International (2017)
Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum
Wojciech Wystrychowski
Stem Cell Research & Therapy (2015)
The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights
Agnes
Molecular and Cellular Endocrinology, 335(1), 2-13 (2011)
The Effect of Turmeric (Curcuma longa) Extract on the Functionality of the Solute Carrier Protein 22 A4 (SLC22A4) and Interleukin-10 (IL-10) Variants Associated with Inflammatory Bowel Disease
Mark J Cann
Nutrients, 6(10) (2014)

Artículos

Mitochondrial Stress and ROS

Oxidative stress is mediated, in part, by reactive oxygen species produced by multiple cellular processes and controlled by cellular antioxidant mechanisms such as enzymatic scavengers or antioxidant modulators. Free radicals, such as reactive oxygen species, cause cellular damage via cellular.

Protocolos

Induced Pluripotent Stem Cell Reprogramming Protocols

Stem cell reprogramming protocols to generate human induced pluripotent stem cells (iPSCs) including viral and non-viral RNA based methods.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico