K1751

Ketoprofen

≥98% (TLC), powder, non-steroidal anti-inflammatory compound

• Sinónimos: 2-(3-Benzoylphenyl)propionic acid
• Fórmula empírica (notación de Hill): C₁₆H₁₄O₃
• Número CAS: 22071-15-4
• Peso molecular: 254.28
• NACRES: NA.77
• PubChem Substance ID: 57654315
• UNSPSC Code: 12352200
• EC Number: 244-759-8
• MDL number: MFCD00055790

Propiedades

• Nombre del producto: Ketoprofen, ≥98% (TLC)
• InChI key: DKYWVDODHFEZIM-UHFFFAOYSA-N
• InChI: 1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
• SMILES string: CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2
• biological source: synthetic
• assay: ≥98% (TLC)
• form: powder
• solubility: ethanol: 50 mg/mL, clear, colorless to yellow
• originator: Bayer
• Quality Level: 200
• Gene Information: human ... ALB(213), IL8RA(3577), PTGS1(5742), PTGS2(5743)

Descripción

Application

Ketoprofen has been used:

• as sample to analyse the effects of long storage period by chromatographic and microscopic techniques[1]
• as a nonselective COX inhibitor to inject subcutaneously in rats to study its effect on stress/methamphetamine hydrochloride-induced changes in occludin, claudin-5 and COX-2 protein immunoreactivity, truncation of β-dystroglycan, brain water content and fluorescein isothiocyanate-dextran extravasation[2]
• in phosphate buffer to study its ability to inhibit heat-induced denaturation of albumin[3]

Biochem/physiol Actions

It serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis.[4] It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase.[5]

Non-steroidal anti-inflammatory compound that is selective for COX-1.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Ketoprofen belongs to the class of 2-arylpropionic acid.[4]

Información de seguridad

• pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H301,H315,H319,H400
• pcodes: P264 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges