Merck
All Photos(3)

1.37004

SAFC

Titriplex® III

(ethylene dinitrilo tetraacetic acid disodium salt dihydrate), EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

Synonym(s):
Edetate disodium salt dihydrate, Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, Edathamil, Disodium dihydrogen ethylenediaminetetraacetate, Ethylenediaminetetraacetic acid disodium salt, Ethylenediaminetetraacetic acid disodium salt dihydrate, EDTA-Na2, Sequestrene Na2
Empirical Formula (Hill Notation):
C10H14N2Na2O8 · 2H2O
CAS Number:
Molecular Weight:
372.24
Beilstein:
3900609
Numer indeksu EC:
205-358-3

Poziom jakości

500

klasa czystości

ACS reagent

Agency

BP
ChP
JP
Ph. Eur.
USP

linia produktu

EMPROVE® EXPERT

forma

solid

pH

4-5 (20 °C, 50 g/L in H2O)

mp

248 °C (dec.) (lit.)

application(s)

biopharma process and formulation
liquid formulation
parenterals
pharmaceutical

temp. przechowywania

no temp limit

SMILES string

O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2

InChI key

OVBJJZOQPCKUOR-UHFFFAOYSA-L

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Opis ogólny

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Zastosowanie

Titriplex® III (EDTA, ethylene dinitrilo tetraacetic acid disodium salt dihydrate) is a commonly used chelating agent. As it is capable of forming complexes with divalent metal cations, it can inhibit diverse enzymes that require such cations for activity. It is broadly used as antioxidant in pharmaceutical formulations and cosmetics and can enhance the function of preservatives. The disodium salt provides improved solubility in water compared to standard EDTA.
Due to its low microbial and endotoxin limits, Titriplex® III (ethylene dinitrilo tetraacetic acid disodium salt dihydrate) Emprove® Expert is especially suitable for high-risk applications.
Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Inne uwagi

Elimination of water of crystallization: 110 °C

Informacje prawne

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
Titriplex is a registered trademark of Merck KGaA, Darmstadt, Germany

Hasło ostrzegawcze

Warning-Warning

Zwroty wskazujące rodzaj zagrożenia

Klasyfikacja zagrożeń

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - STOT RE 2 Inhalation

Organy docelowe

Respiratory Tract

Kod klasy składowania

11 - Combustible Solids

WGK

WGK 2

Temperatura zapłonu °F

Not applicable

Temperatura zapłonu °C

Not applicable

What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials.

Material Qualification Dossier

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Quality Management Dossier

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Operational Excellence Dossier

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Why are these documents unavailable?
Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

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