D1068

DCB

≥98% (HPLC), solid

• Synonim(y): 3,3′-Dichlorobenzaldazine, NSC 67224
• Wzór empiryczny (zapis Hilla): C₁₄H₁₀Cl₂N₂
• Numer CAS: 6971-97-7
• Masa cząsteczkowa: 277.15
• NACRES: NA.77
• PubChem Substance ID: 24724458
• UNSPSC Code: 12352200
• MDL number: MFCD00556081
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated, under inert gas

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated, under inert gas
• color: yellow
• solubility: DMSO: ~6.8 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: Clc1cccc(\C=N\N=C\c2cccc(Cl)c2)c1
• InChI: 1S/C14H10Cl2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+
• InChI key: XMOVWXSCYLINBJ-BEQMOXJMSA-N

Opis

Biochem/physiol Actions

3,3′-dichlorobenzaldazine (DCB) serves as an allosteric ligand with neutral cooperativity. It helps to block the positive allosteric regulation of mGluRs (metabotropic glutamate receptor subtype 5 (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) and the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB).

Neutral allosteric modulator of the metabotropic glutamate receptor mGluR₅.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS05,GHS07,GHS09
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H302,H315,H317,H318,H335,H410
• Ostrzeżenia: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Narządy docelowe: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Faceshields, Gloves