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G0635

Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate

Name: Guanosine 5&#8242;-[&#946;,&#947;-imido]triphosphate trisodium salt hydrate
Brand: SIGMA

≥85% (HPLC), synthetic (organic), powder

Synonim(y):

β:γ-Imidoguanosine 5′-triphosphate trisodium salt hydrate, 5′-Guanylyl-imidodiphosphate trisodium salt hydrate, GMP-PNP, Gpp(NH)p

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₀H₁₄N₆Na₃O₁₃P₃ · xH₂O

Numer CAS:

148892-91-5

Masa cząsteczkowa:

588.14 (anhydrous basis)

UNSPSC Code:

41106305

PubChem Substance ID:

24895020

NACRES:

NA.51

MDL number:

MFCD00084770

eCl@ss:

32119108

Assay:

≥85% (HPLC)

Biological source:

synthetic (organic)

Form:

powder

Solubility:

H₂O: 50 mg/mL

Storage temp.:

−70°C

Informacje o cenach i dostępności nie są obecnie dostępne.

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Właściwości

Nazwa produktu

Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate, ≥85% (HPLC), powder

biological source

synthetic (organic)

Quality Segment

200

assay

≥85% (HPLC)

form

powder

color

white

solubility

H₂O: 50 mg/mL

shipped in

dry ice

storage temp.

−70°C

SMILES string

[Na+].[Na+].[Na+].Nc1nc(O)c2ncn([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP(O)([O-])=O)[C@@H](O)[C@H]3O)c2n1

InChI

1S/C10H17N6O13P3.3Na/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22;;;/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1

InChI key

QGJNRMUNXAROIT-CYCLDIHTSA-K

Opis

General description

Guanosine 5′-[β,γ-imido]triphosphate (GMP-PNP, Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding, including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis, and GTP structure stabilization. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, guanosine 5′-[β,γ-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling, protein synthesis and other metabolic processes.

Application

Non-hydrolyzable analog of GTP; the preferred GTP analog to activate ADP-ribosylation factor.

Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate has been used: to study K-RAS interactions with the membrane, for the crystallization of Mycobacterium tuberculosis FtsZ, as a translation initiation inhibitor for the analysis of the 48S pre-initiation complex.

Biochem/physiol Actions

Guanosine 5′-[β,γ-imido]triphosphate binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.

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Ta pozycja	M3509	A2647	G8634
Sigma-Aldrich G0635 Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate	Sigma-Aldrich M3509 β,γ-Methyleneguanosine 5′-triphosphate sodium salt	Sigma-Aldrich A2647 Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate	Sigma-Aldrich G8634 Guanosine 5′-[γ-thio]triphosphate tetralithium salt
description ≥85% (HPLC), powder	description ≥98% (HPLC)	description ≥93% (HPLC), powder	description ≥90% (contains < 10% GDP, HPLC), powder
biological source synthetic (organic)	biological source synthetic (organic)	biological source natural (organic)	biological source -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
assay ≥85% (HPLC)	assay ≥98% (HPLC)	assay ≥93% (HPLC)	assay ≥90% (contains < 10% GDP, HPLC)
form powder	form powder	form powder	form powder
storage temp. −70°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
color white	color -	color white	color white to off-white