M1434

2-Methylthioadenosine 5′-monophosphate triethylammonium salt hydrate

≥98% (HPLC), solid

• Synonim(y): 2-MeSAMP, 2-Methylthio-AMP triethylammonium salt hydrate
• Wzór empiryczny (zapis Hilla): C₁₁H₁₆N₅O₇PS · xC₆H₁₅N × yH₂O
• Numer CAS: 22140-20-1
• Masa cząsteczkowa: 393.31 (anhydrous free acid basis)
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• PubChem Substance ID: 24896647
• NACRES: NA.51
• Assay: ≥98% (HPLC)
• Form: solid
• Solubility: H₂O: 20 mg/mL, clear, colorless
• Storage temp.: −20°C

Właściwości

• Nazwa produktu: 2-Methylthioadenosine 5′-monophosphate triethylammonium salt hydrate, solid, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white
• solubility: H₂O: 20 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: O.CCN(CC)CC.CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1
• InChI: 1S/C11H16N5O7PS.C6H15N.H2O/c1-25-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(23-10)2-22-24(19,20)21;1-4-7(5-2)6-3;/h3-4,6-7,10,17-18H,2H2,1H3,(H2,12,14,15)(H2,19,20,21);4-6H2,1-3H3;1H2/t4-,6-,7-,10-;;/m1../s1
• InChI key: YQMUWWZKFZERBT-IDIVVRGQSA-N

Opis

Application

2-Methylthioadenosine 5′-monophosphate triethylammonium salt hydrate has been used:

• as a P2Y₁₂ inhibitor to study its effects on stimulation of endocytosis in high-density lipoprotein (HDL).
• as a P2Y₁₂ inhibitor to study its effects on platelet recruitment in whole human blood.

Biochem/physiol Actions

2-Methylthioadenosine5′-monophosphate triethylammonium salt (2-MeSAMP) is an adenosine-based P2Y₁₂ antagonist and ADP-dependent platelet aggregation inhibitory agent.(1) It has a potential to inhibit platelet activation throughP2Y₁₂/G(i)-dependent mechanism.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)