P8783

Progesterone

powder, BioReagent, suitable for cell culture

• Synonim(y): 4-Pregnene-3,20-dione
• Empirical Formula (Hill Notation): C₂₁H₃₀O₂
• Numer CAS: 57-83-0
• Masa cząsteczkowa: 314.46
• Beilstein: 1915950
• Numer EC: 200-350-6
• Numer MDL: MFCD00003658
• Identyfikator substancji w PubChem: 24898978

Właściwości

• pochodzenie biologiczne: synthetic (organic)
• Poziom jakości: 200
• opis: synthesized from materials derived from plant source
• linia produktu: BioReagent
• Próba: ≥99%
• forma: powder
• siła działania: 0.1-20 ng/mL
• technique(s): cell culture | mammalian: suitable
• mp: 128-132 °C (lit.)
• rozpuszczalność: absolute ethanol: 1 mg/mL
• temp. przechowywania: room temp
• SMILES string: CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
• InChI key: RJKFOVLPORLFTN-LEKSSAKUSA-N
• Gene Information: human ... ABCB1(5243) , AR(367) , CYP2C9(1559) , EBP(10682) , ESR1(2099) , ESR2(2100) , NR3C1(2908) , NR3C2(4306) , PGR(5241) , SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Ar(24208) , Nr3c1(24413) , Pgr(25154)

Opis

Opis ogólny

Progesterone is a steroid hormone secreted by the ovaries.

Zastosowanie

Progesterone has been used:

• as a growth-promoting hormone in basal medium for bovine mammary epithelial cell culture
• to test its neuroprotective abilities in a well-characterized lateral cortical contusion injury (CCI) model
• as an endocytosis inhibitor to study its effect on Coxsackievirus A9 infection on A549 cells

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

Działania biochem./fizjol.

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.

Inne uwagi

Steroid hormone produced by the corpus luteum.

Postać fizyczna

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Rekonstytucja

To prepare 20μg/ml stock solution, add 1ml absolute ethanol per mg progesterone, gently swirl to dissolve, add 49ml sterile medium per ml ethanol.

Informacja o środkach bezpieczeństwa

• piktogramy: GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H351 - H360FD - H362
• Zwroty wskazujące środki ostrożności: P202 - P260 - P263 - P264 - P280 - P308 + P313
• Klasyfikacja zagrożeń: Carc. 2 - Lact. - Repr. 1A
• Kod klasy składowania: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Temperatura zapłonu °F: Not applicable
• Temperatura zapłonu °C: Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges