SML1068

TIC10 angular

≥98% (HPLC)

• Synonim(y): 7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one., ONC-201, ONC201, TIC10 corrected
• Wzór empiryczny (zapis Hilla): C₂₄H₂₆N₄O
• Masa cząsteczkowa: 386.49
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear
• storage temp.: 2-8°C

Opis

General description

TIC10 (TRAIL-inducing compound 10) is an anticancer molecule also referred as ONC201.

Biochem/physiol Actions

TIC10 angular is a potent blood brain barrier penetrant and orally active inducer of TRAIL production that induces death of multiple human cancers.

TIC10 angular is a potent blood brain barrier penetrant and orally active inducer of TRAIL production that induces death of multiple human cancers. TIC10 angular inactivates both Akt and ERK, which results in Foxo3a nuclear factor migration to the nucleus and binding to TRAIL promoter.

TIC10 (TRAIL-inducing compound 10) induces apoptosis mediated by TRAIL (TNF-related apoptosis-inducing ligand) in a number of cancers without toxicity such as breast, colon and glioblastoma multiforme tumors.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS09
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H410
• Ostrzeżenia: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable