1365000

Lewotyroksyna

United States Pharmacopeia (USP) Reference Standard

• Synonim(y): L-Thyroxine, 3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T₄
• Wzór liniowy: HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H
• Numer CAS: 51-48-9
• Masa cząsteczkowa: 776.87
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329750052
• MDL number: MFCD00002595
• Beilstein/REAXYS Number: 2228515

Właściwości

• grade: pharmaceutical primary standard
• agency: USP
• API family: levothyroxine
• form: crystalline powder
• manufacturer/tradename: USP
• color: yellow
• mp: 223 °C (dec.) (lit.)
• application(s): pharmaceutical (small molecule); pharmaceutical
• format: neat
• storage temp.: 2-8°C
• SMILES string: N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
• InChI: 1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
• InChI key: XUIIKFGFIJCVMT-LBPRGKRZSA-N
• Gene Information: human ... THRA(7067), THRB(7068)

Opis

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Wzorzec referencyjny lewotyroksyny USP, przeznaczony do stosowania w określonych testach jakości i oznaczeniach, jak określono w kompendiach USP. Również do użytku z monografiami USP, takimi jak:

• Levothyroxine Sodium
• Lewotyroksyna sodowa w tabletkach
• Sól sodowa lewotyroksyny w proszku do podawania doustnego
• Liothyronine Sodium
• Tarczyca
• Tabletki na tarczycę
• Liothyronine Sodium Tabletki

Biochem/physiol Actions

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H372
• Ostrzeżenia: P260 - P264 - P270 - P314 - P501
• Hazard Classifications: STOT RE 1
• Narządy docelowe: Thyroid,Cardio-vascular system,Kidney
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable