1396309

Metformina

United States Pharmacopeia (USP) Reference Standard

• Synonim(y): 1,1-Dimethylbiguanide hydrochloride, Metformin
• Wzór liniowy: NH₂C(=NH)NHC(=NH)N(CH₃)₂ · HCl
• Numer CAS: 1115-70-4
• Masa cząsteczkowa: 165.62
• NACRES: NA.24
• PubChem Substance ID: 329750380
• UNSPSC Code: 41116107
• MDL number: MFCD00012582
• eCl@ss: 25140904

Właściwości

• grade: pharmaceutical primary standard
• agency: USP
• API family: metformin
• manufacturer/tradename: USP
• mp: 223-226 °C (lit.)
• application(s): pharmaceutical (small molecule); pharmaceutical
• format: neat
• SMILES string: Cl[H].CN(C)C(=N)NC(N)=N
• InChI: 1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
• InChI key: OETHQSJEHLVLGH-UHFFFAOYSA-N
• Gene Information: —

Opis

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Metformin hydrochloride USP reference standard for specified tests and assay use.

Also used to prepare standard, mixed standard stock and system suitability solutions for the assay, impurity analysis and performance tests according to the given below monographs of United States Pharmacopeia (USP):

• Metformin Hydrochloride
• Pioglitazone and Metformin Hydrochloride Tablets
• Metformin Hydrochloride Tablets
• Glyburide and Metformin Hydrochloride Tablets

Biochem/physiol Actions

Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302,H319
• Ostrzeżenia: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable