ABD136

Anti-LGI1 Antibody

from rabbit, purified by affinity chromatography

• Synonym(s): Leucine-rich glioma inactivated protein 1, Epitempin-1
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: -

Properties

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: mouse
• species reactivity (predicted by homology): human (immunogen homology)
• technique(s): western blot: suitable
• UniProt accession no.: O95970
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... LGI1(9211)

Description

General description

Leucine-rich glioma inactivated gene 1 (LGI1), also known as Epitempin-1 (EPT), is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) regulating voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. LGI1 may play a role in the control of neuroblastoma cell survival and may play a role in other cancers. It is expressed in neural tissue, especially brain. Mutations in LGI1 have been associated with nearly half of autodominant lateral temporal epilepsy (ADTLE).

~56 kDa observed. Uniprot describes 3 isoforms at ~33 kDa, ~58 kDa, and ~64 kDa Uncharacterized bands may appear in some lysates.

Immunogen

KLH-conjugated linear peptide corresponding to the N-terminus of human LGI1.

Application

Detect LGI1 using this rabbit polyclonal antibody, Anti-LGI1 Antibody validated for use in western blotting.

Biochem/physiol Actions

This antibody recognizes the N-terminus of LGI1.

Analysis Note

Evaluated by Western Blotting/Peptide Inhibition Assay in mouse brain tissue lysate.

Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected LGI1 in 15 µg of mouse brain tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• WGK: WGK 2