A9730

Adefovir dipivoxil

• Synonym(s): 9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine
• Empirical Formula (Hill Notation): C₂₀H₃₂N₅O₈P
• CAS Number: 142340-99-6
• Molecular Weight: 501.47
• NACRES: NA.76
• PubChem Substance ID: 329771057
• UNSPSC Code: 51102829
• MDL number: MFCD00869897

Properties

• biological source: synthetic
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: ethanol: 50 mg/mL
• antibiotic activity spectrum: viruses
• mode of action: enzyme | inhibits
• storage temp.: −20°C
• SMILES string: CC(C)(C)C(=O)OCOP(=O)(COCCn1cnc2c(N)ncnc12)OCOC(=O)C(C)(C)C
• InChI: 1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)
• InChI key: WOZSCQDILHKSGG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analog that works by blocking reverse transcriptase. It is an inhibitor of duck hepatitis B virus (DHBV) replication that inhibits covalently closed circular DNA (CCC DNA) amplification. Cytotxicity is induced by Human Renal Organic Anion Transporter 1 (hOAT1). Adefovir is an Inhibitor of edema factor (EF)-induced cAMP accumulation and changes in cytokine production in mouse primary macrophages .

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302 + H312 + H332
• Precautionary Statements: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves