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(S)-(−)-Bay K8644

Name: (<I>S</I>)-(&#8722;)-Bay K8644
Brand: SIGMA
Price: 261 USD
Availability: InStock

≥98% (HPLC), Ca2+ channel activator, solid

Synonym(s):

S-(−)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

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Size/SKU	Availability	Price
1 mg	Check Cart for Availability	$261.00
5 mg	Check Cart for Availability	$997.00

About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₅F₃N₂O₄

CAS Number:

98625-26-4

Molecular Weight:

356.30

UNSPSC Code:

12352200

PubChem Substance ID:

24891582

NACRES:

NA.77

MDL number:

MFCD00153769

Assay:

≥98% (HPLC)

Form:

solid

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Properties

Product Name

(S)-(−)-Bay K8644, ≥98% (HPLC), solid

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

H₂O: slightly soluble, ethanol: soluble (Organic solutions are stable for at least 20 days at RT.)

storage temp.

2-8°C

SMILES string

COC(=O)C1=C(C)NC(C)=C([C@H]1c2ccccc2C(F)(F)F)[N+]([O-])=O

InChI

1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1

InChI key

ZFLWDHHVRRZMEI-ZDUSSCGKSA-N

Gene Information

human ... ADORA3(140)
rat ... Adora1(29290), Adora2a(25369)

Description

General description

(S)-(-)-Bay K8644, a dihydropyridine compound is a Ca²⁺ channel activator. It is an enantiomer of Bay K 8644.

Application

(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmia in rats.

Biochem/physiol Actions

(S)-(-)-Bay K8644 enhances Ca²⁺ current, whereas the (+)-Bay K 8644 is a weak Ca²⁺ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Manufactured and sold with the permission of Bayer AG.

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Show Differences

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This Item	543527	647446	70942
Sigma-Aldrich B133 (S)-(−)-Bay K8644	Sigma-Aldrich 543527 (S)-(−)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride	Sigma-Aldrich 647446 (S)-(−)-2-Aminomethyl-1-ethylpyrrolidine	Sigma-Aldrich 70942 (S)-(−)-1-(2-Naphthyl)ethylamine
description ≥98% (HPLC), solid	description 97%	description 96%	description ≥99.0% (sum of enantiomers, GC)
form solid	form -	form -	form solid
assay ≥98% (HPLC)	assay 97%	assay 96%	assay ≥99.0% (sum of enantiomers, GC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. -	storage temp. -	storage temp. -
solubility H₂O: slightly soluble, ethanol: soluble (Organic solutions are stable for at least 20 days at RT.)	solubility -	solubility -	solubility -
color yellow	color -	color -	color -

Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H315,H319

Precautionary Statements

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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