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D1634

Diosgenin

≥93%, apoptosis inducer, powder

Synonym(s):

(25R)-5-Spirosten-3β-ol, 3β-Hydroxy-5-spirostene, Nitogenin

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Size/SKUAvailabilityPrice
5 g
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$78.10
100 g
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$862.00

About This Item

Empirical Formula (Hill Notation):
C27H42O3
CAS Number:
512-04-9
Molecular Weight:
414.62
NACRES:
NA.77
PubChem Substance ID:
24893501
UNSPSC Code:
12352200
EC Number:
208-134-3
MDL number:
MFCD00016887
Beilstein/REAXYS Number:
94582
Assay:
≥93%
Form:
powder

$78.10

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Product Name

Diosgenin, ≥93%

Quality Segment

assay

≥93%

form

powder

SMILES string

[H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]6(CC[C@@H](C)CO6)O2

InChI

1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1

InChI key

WQLVFSAGQJTQCK-VKROHFNGSA-N

Gene Information

human ... UGT1A4(54657)

General description

Diosgenin is a triterpene and a glycone derivative of dioscin. Yams, Trigonella foenum-graecum and Costus speciosus are some of its source.

Application

Diosgenin has been:
  • used as a standard in the analysis of total saponins in Sapindus rarak
  • orally administered to the rats to study its role against atherogenic diet-induced production of inflammatory mediators in heart, liver and brain
  • used as a standard compound to determine the saponins content in chickpea and Tribulus terrestris

Biochem/physiol Actions

Diosgenin induces apoptosis in colon cancer cell lines and induces apoptosis, cell cycle arrest and cyclooxygenase activity in osteosarcoma cells. It serves as a precursor in steroid drug production. Diosgenin is shown to promote cholesterol production by stimulating biliary excretion. It influences lipoxygenase induced human erythroleukemia cell line differentiation.

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This Item
Y0001871AMBH95E07087PHL89649
Diosgenin ≥93%

Sigma-Aldrich

D1634

Diosgenin

Diosgenin European Pharmacopoeia (EP) Reference Standard

Y0001871

Diosgenin

(2'R,4S,5'R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5',6a,8a,9-Tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol

Ambeed, Inc.

AMBH95E07087

(2'R,4S,5'R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5',6a,8a,9-Tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol

Diosgenin phyproof® Reference Substance

PHL89649

Diosgenin

description

≥93%

description

European Pharmacopoeia (EP) Reference Standard

description

-

description

phyproof® Reference Substance

assay

≥93%

assay

-

assay

-

assay

≥98.0% (HPLC)

form

powder

form

-

form

-

form

solid

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

Gene Information

human ... UGT1A4(54657)

Gene Information

-

Gene Information

-

Gene Information

-

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Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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