E7280

Elafin

recombinant, expressed in Saccharomyces cerevisiae, powder, >90% (by MS, HPLC and SDS-PAGE),

• Synonym(s): Elastase-specific inhibitor, skin-derived antileukoprotease
• UNSPSC Code: 12352202
• NACRES: NA.77
• MDL number: MFCD00146824

Properties

• Product Name: Elafin human, >90% (by MS, HPLC and SDS-PAGE), recombinant, expressed in Saccharomyces cerevisiae
• Quality Segment: 200
• recombinant: expressed in Saccharomyces cerevisiae
• assay: >90% (by MS, HPLC and SDS-PAGE)
• form: powder
• potency: 1.7 x 10-10 M K_i (human leukocyte elastase), 4.2 x 10-10 M K_i (human proteinase 3)
• mol wt: ~6 kDa
• UniProt accession no.: P19957
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: enzyme | inhibits
• shipped in: ambient
• storage temp.: −20°C
• Gene Information: human ... PI3(5266)

Description

General description

Chemical structure: peptide

Biochem/physiol Actions

Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.

Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage.

Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)