L1663

Lidocaine N-ethyl chloride

Name: Lidocaine N-ethyl chloride
Brand: SIGMA
Price: 374 USD

sodium channel blocker

Synonym(s):

N-(2,6-Dimethylphenylcarbamoylmethyl) triethylammonium chloride

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₇N₂OCl

CAS Number:

5369-03-9

Molecular Weight:

298.85

UNSPSC Code:

12352200

PubChem Substance ID:

24896288

NACRES:

NA.77

MDL number:

MFCD01669894

Key Documents

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Product Name

Lidocaine N-ethyl chloride,

SMILES string

[Cl-].CC[N+](CC)(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H

InChI key

LLPPOMUAOGMYQI-UHFFFAOYSA-N

storage condition

protect from light

solubility

H₂O: soluble

storage temp.

room temp

Quality Level

100

Related Categories

Bioactive Small Molecules

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This Item	SML1444	C4382	D2926
Sigma-Aldrich L1663 Lidocaine N-ethyl chloride	Sigma-Aldrich SML1444 (±)-Mepivacaine hydrochloride	Sigma-Aldrich C4382 Carbamoylcholine chloride	Sigma-Aldrich D2926 Diphenyleneiodonium chloride
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 300
storage temp. room temp	storage temp. room temp	storage temp. -	storage temp. room temp
solubility H₂O: soluble	solubility H₂O: 20 mg/mL, clear	solubility H₂O: 1 g/mL, ethanol: 20 mg/mL	solubility DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
storage condition protect from light	storage condition desiccated	storage condition -	storage condition -

Other Notes

Stable at room temperature lyophilized. In solution, store at 4 °C for up to two weeks. Store solutions at -20 °C for up to six months.

Biochem/physiol Actions

Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Cell type-specific modulation of sensory and affective components of itch in the periaqueductal gray.

Vijay K Samineni et al.

Nature communications, 10(1), 4356-4356 (2019-09-27)

Itch is a distinct aversive sensation that elicits a strong urge to scratch. Despite recent advances in our understanding of the peripheral basis of itch, we know very little regarding how central neural circuits modulate acute and chronic itch processing.

Co-Application of Eugenol and QX-314 Elicits the Prolonged Blockade of Voltage-Gated Sodium Channels in Nociceptive Trigeminal Ganglion Neurons.

Sung-Min Hwang et al.

Biomolecules, 10(11) (2020-11-11)

Local anesthetics (LAs) can completely block nociception by inhibiting voltage-gated sodium channels (VGSCs), and thus, blocking action potentials (APs) within sensory neurons. As one of the several LAs, eugenol is used for dental pain treatment. It reportedly features multiple functions

Functional Voltage-Gated Calcium Channels Are Present in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium.

Iina Korkka et al.

Stem cells translational medicine, 8(2), 179-193 (2018-11-06)

Retinal pigment epithelium (RPE) performs important functions for the maintenance of photoreceptors and vision. Malfunctions within the RPE are implicated in several retinal diseases for which transplantations of stem cell-derived RPE are promising treatment options. Their success, however, is largely

Role of P2X4 receptors in synaptic strengthening in mouse CA1 hippocampal neurons.

Andrew W Baxter et al.

The European journal of neuroscience, 34(2), 213-220 (2011-07-14)

P2X4 receptors are calcium-permeable cation channels gated by extracellular ATP. They are found close to subsynaptic sites on hippocampal CA1 neurons. We compared features of synaptic strengthening between wild-type and P2X4 knockout mice (21-26 days old). Potentiation evoked by a

BDNF-induced presynaptic facilitation of GABAergic transmission in the hippocampus of young adults is dependent of TrkB and adenosine A2A receptors.

Mariana Colino-Oliveira et al.

Purinergic signalling, 12(2), 283-294 (2016-02-22)

Brain-derived neurotrophic factor (BDNF) and adenosine are widely recognized as neuromodulators of glutamatergic transmission in the adult brain. Most BDNF actions upon excitatory plasticity phenomena are under control of adenosine A2A receptors (A2ARs). Concerning gamma-aminobutyric acid (GABA)-mediated transmission, the available

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Lidocaine N-ethyl chloride