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S166

Saclofen

solid

Synonym(s):

β-(Aminomethyl)-4-chlorobenzeneethanesulfonic acid

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAY

$349.00

About This Item

Empirical Formula (Hill Notation):
C9H12ClNO3S
CAS Number:
125464-42-8
Molecular Weight:
249.71
NACRES:
NA.32
PubChem Substance ID:
329824485
UNSPSC Code:
51111800
MDL number:
MFCD00216817
Form:
solid

$349.00

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form

solid

Quality Segment

color

white

solubility

0.1 M NaOH: 20 mg/mL

SMILES string

NCC(CS(O)(=O)=O)c1ccc(Cl)cc1

InChI

1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)

InChI key

JYLNVJYYQQXNEK-UHFFFAOYSA-N

Gene Information

Application

Saclofen has been used to prevent the inhibitory action of oxytocin on capsaicin-induced glutamatergic spontaneous excitatory transmission in rat neurons.
Saclofen has been used as a GABAB receptor antagonist to study the analgesic effect of repeated injections of oxycodone in rats.

Biochem/physiol Actions

Saclofen might possess sympathetic nervous system-dependent anti-inflammatory action.
Saclofen is the sulphonic analog of baclofen and is a selective GABAB receptor antagonist.

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This Item
A6566M196G154
Saclofen solid

Sigma-Aldrich

S166

Saclofen

2-Hydroxysaclofen ≥98% (TLC), solid

Sigma-Aldrich

A6566

2-Hydroxysaclofen

(+)-α-Methyl-4-carboxyphenylglycine solid

Sigma-Aldrich

M196

(+)-α-Methyl-4-carboxyphenylglycine

Gabapentin solid

Sigma-Aldrich

G154

Gabapentin

description

solid

description

≥98% (TLC), solid

description

solid

description

solid

form

solid

form

solid

form

solid

form

solid

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

solubility

0.1 M NaOH: 20 mg/mL

solubility

0.1 M NaOH: 9.5 mg/mL, methanol: 1.4 mg/mL, DMSO: 28 mg/mL, 0.1 M HCl: 1.2 mg/mL, H2O: 1 mg/mL

solubility

0.1 M NaOH: 15 mg/mL

solubility

H2O: 10 mg/mL

color

white

color

white

color

-

color

off-white

Gene Information

human ... GABBR1(2550), GABBR2(9568)
mouse ... GABBR1(54393), GABBR2(242425)
rat ... GABBR1(81657), GABBR2(83633)

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Gene Information

rat ... Grm1(24414)

Gene Information

human ... ADORA1(134), CACNA1A(773), CACNA1B(774), CACNA1C(775), CACNA1D(776), CACNA1E(777), CACNA1F(778), CACNA1G(8913), CACNA1H(8912), CACNA1I(8911), CACNA1S(779), CACNA2D1(781), CACNA2D2(9254), CACNA2D3(55799), CACNA2D4(93589), CACNB1(782), CACNB2(783), CACNB3(784), CACNB4(785), CACNG1(786), CACNG2(10369), CACNG3(10368), CACNG4(27092), CACNG5(27091), CACNG6(59285), CACNG7(59284), CACNG8(59283)
rat ... Cacna1a(25398)

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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