SML0909

Nefopam hydrochloride

≥98% (HPLC), neurotransmitter reuptake inhibitor, powder

• Synonym(s): 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride, 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine hydrochloride
• Empirical Formula (Hill Notation): C₁₇H₁₉NO · HCl
• CAS Number: 23327-57-3
• Molecular Weight: 289.80
• NACRES: NA.77
• PubChem Substance ID: 329825616
• UNSPSC Code: 12352200
• EC Number: 245-585-5
• MDL number: MFCD00012750
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: Nefopam hydrochloride, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• mp: 260 °C (dec.) (lit.)
• solubility: H₂O: 5 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Cl.CN1CCOC(c2ccccc2)c3ccccc3C1
• InChI: 1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H
• InChI key: CNNVSINJDJNHQK-UHFFFAOYSA-N

Description

Application

Nefopam hydrochloride has been used as a standard for the quantitative determination of tramadol by gas chromatography–mass spectrometry (GC/MS).

Biochem/physiol Actions

Nefopam is a centrally-acting analgesic drug of the benzoxazocine chemical class. Nefopam is a non-opioid, but has a potentiating effect on morphine and other opioids. Its mechanism of action is not certain, but may involve its action as a dopamine/serotonin/norepinephrine reuptake inhibitor.

Nefopam is a centrally-acting non-opioid analgesic drug of the benzoxazocine chemical class.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Codes: H301 + H311 + H331
• Precautionary Statements: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable