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SML2212

RWJ 67657

≥98% (HPLC)

Synonym(s):

3-Butyn-1-ol, 4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl], 4-(4-Fluorophenyl)-2-(4-hydroxy-1-butynyl)-1-(3-Phenylpropyl)-5-(4-Pyridyl)imidazole, 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol, JNJ 3026582

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Size/SKUAvailabilityPrice
5 mg
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$91.40

About This Item

Empirical Formula (Hill Notation):
C27H24FN3O
CAS Number:
Molecular Weight:
425.50
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$91.40


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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OCCC#CC1=NC(C2=CC=C(F)C=C2)=C(C3=CC=NC=C3)N1CCCC4=CC=CC=C4

InChI

1S/C27H24FN3O/c28-24-13-11-22(12-14-24)26-27(23-15-17-29-18-16-23)31(25(30-26)10-4-5-20-32)19-6-9-21-7-2-1-3-8-21/h1-3,7-8,11-18,32H,5-6,9,19-20H2

InChI key

QSUSKMBNZQHHPA-UHFFFAOYSA-N

Biochem/physiol Actions

RWJ 67657 is an orally active, potent and selective inhibitor of p38α and p38β MAP kinases. RWJ 67657 inhibits the release of TNF-α and IL-1β from LPS induced blood mononuclear cells. It exhibits cardioprotective and anti-inflammatory activities in vivo.
orally active, potent and selective inhibitor of p38α and p38β MAP kinases

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SAB5600059EMU147801
description

≥98% (HPLC)

description

recombinant, expressed in HEK 293 cells, clone RM245, purified immunoglobulin

description

targeting mouse Rabl3

form

powder

form

buffered aqueous glycerol solution

form

lyophilized powder

assay

≥98% (HPLC)

assay

-

assay

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

color

white to beige

color

-

color

-

RWJ 67657 TNF-α IL-1β release inhibitor

-

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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