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W2020

WR-1065

≥98% (HPLC), reactive oxygen species scavenger, powder

Synonym(s):

2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride, WR-1065 dihydrochloride

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$111.00

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About This Item

Empirical Formula (Hill Notation):
C5H14N2S · 2HCl
CAS Number:
14653-77-1
Molecular Weight:
207.16
UNSPSC Code:
12352200
PubChem Substance ID:
329830444
NACRES:
NA.77
MDL number:
MFCD00460339
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

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Product Name

WR-1065, ≥98% (HPLC)

SMILES string

Cl.Cl.NCCCNCCS

InChI key

XDRLRDHLCIFZIW-UHFFFAOYSA-N

InChI

1S/C5H14N2S.2ClH/c6-2-1-3-7-4-5-8;;/h7-8H,1-6H2;2*1H

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

H2O: ≥20 mg/mL

storage temp.

−20°C

Quality Level

100

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WR-1065 ≥98% (HPLC)

Sigma-Aldrich

W2020

WR-1065

BD 1063 dihydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0276

BD 1063 dihydrochloride

Acotiamide dihydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1569

Acotiamide dihydrochloride

AZD6765 dihydrochloride ≥97% (HPLC)

Sigma-Aldrich

SML0635

AZD6765 dihydrochloride

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

room temp

storage temp.

−20°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

solubility

H2O: ≥20 mg/mL

solubility

H2O: >15 mg/mL

solubility

H2O: 20 mg/mL, clear

solubility

H2O: 20 mg/mL, clear

Biochem/physiol Actions

WR-1065 is a cytoprotective cell-permeable ROS scavenge and an active metabolite of Amifostine.
WR-1065 is cytoprotective cell-permeable reactive oxygen species scavenger and p53 activator and re-activator. Recently shown to have antiretroviral activity and an active metabolite of Amifostine which selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy.
WR-1065 is the active metabolite of the prodrug amifostine, generated by alkaline phosphatase.[1] It is found to accumulate in many epithelial tissues.[2] WR-1065 protects cellular membranes and DNA from free radical induced damage.[1]

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

hcodes

H302,H318

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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