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Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression.

Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression.

Oncoimmunology (2015-09-26)

Wendy Wj Unger, Christian T Mayer, Steef Engels, Christina Hesse, Maurizio Perdicchio, Franz Puttur, Ingeborg Streng-Ouwehand, Manja Litjens, Hakan Kalay, Luciana Berod, Tim Sparwasser, Yvette van Kooyk

ABSTRACT

Therapeutic vaccinations against cancer are still largely ineffective. Major caveats are inefficient delivery of tumor antigens to dendritic cells (DCs) and excessive immune suppression by

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