Merck
All Photos(4)

271004

Sigma-Aldrich

Acetonitrile

anhydrous, 99.8%

Sign Into View Organizational & Contract Pricing

Select a Size

Synonym(s):
ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide
Linear Formula:
CH3CN
CAS Number:
Molecular Weight:
41.05
Beilstein:
741857
EC Number:
MDL number:
eCl@ss:
39031501
PubChem Substance ID:
NACRES:
NA.21

grade

anhydrous

Quality Level

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)

Assay

99.8%

form

liquid

autoignition temp.

973 °F

expl. lim.

16 %

technique(s)

solid phase extraction (SPE): suitable

impurities

<0.001% water
<0.005% water (100 mL pkg)

evapn. residue

<0.0005%

color

colorless

refractive index

n20/D 1.344 (lit.)

bp

81-82 °C (lit.)

mp

−45 °C (lit.)

solubility

water: soluble (completely)

density

0.786 g/mL at 25 °C (lit.)

format

neat

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
360457110086CN34892
Acetonitrile anhydrous, 99.8%

Sigma-Aldrich

271004

Acetonitrile

-
Acetonitrile ACS reagent, &#8805;99.5%

Sigma-Aldrich

360457

Acetonitrile

Essential Grade
Acetonitrile ReagentPlus&#174;, 99%

Sigma-Aldrich

110086

Acetonitrile

-
Acetonitrile Preparateur, &#8805;99.9% (GC), Customized plastic drum

Sigma-Aldrich

CN34892

Acetonitrile

-
vapor density

1.41 (vs air)

vapor density

1.41 (vs air)

vapor density

1.41 (vs air)

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)

vapor pressure

72.8 mmHg ( 20 °C)

vapor pressure

72.8 mmHg ( 20 °C)

vapor pressure

72.8 mmHg ( 20 °C)

assay

99.8%

assay

≥99.5%

assay

99%

assay

≥99.9% (GC)

form

liquid

form

liquid

form

liquid

form

liquid

autoignition temp.

973 °F

autoignition temp.

973 °F

autoignition temp.

973 °F

autoignition temp.

973 °F

General description

Acetonitrile, an aliphatic nitrile, is widely used as an organic solvent and intermediate in organic syntheses. It is transparent to UV-visible light, which makes it highly applicable in spectrophotometric and fluorimetric techniques. MeCN is utilized as a mobile phase component in many chromatographic techniques, due to its low viscosity, high elution strength and miscibility in water. It also plays a major role as an extractant medium in liquid-liquid extraction, solid-phase extraction or microextraction.

Application

Acetonitrile may be used as a solvent to prepare:
  • 1,2-Azidoalcohols and 1,2-azidoamines via cerium(III) chloride assisted ring opening of epoxides and aziridines by sodium azide.
  • Cyano-bearing indolinones by oxidative arylalkylation of olefins in the presence of palladium catalyst.

It may also be used as a reactant to synthesize:
  • Bis (diphenylphosphino) acetonitrile by reacting with n-butyllithium and then with chlorodiphenylphosphine.
  • β-Acetamido ketones via coupling reaction with ketones or ketoesters and aldehydes in the presence of cobalt(II) chloride.

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2.0 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 2

1 of 2

Acetonitrile for gas chromatography ECD and FID SupraSolv&#174;

Supelco

1.00017

Acetonitrile

Acetonitrile gradient grade for liquid chromatography LiChrosolv&#174; Reag. Ph Eur

Supelco

1.00030

Acetonitrile

Cobalt-catalysed three-component coupling involving ketones or ketoesters, aldehydes and acetonitrile: a novel one-pot synthesis of ?-acetamido ketones
Madhavaa Reddy M.
Journal of the Chemical Society. Chemical Communications, 6, 713-714 (1994)
Bis (diphenylphosphino) acetonitrile: Synthesis, ligand properties and application in catalytic carbon?carbon coupling
Braun L, et al.
Dalton Transactions, 14, 1409-1415 (2007)
Cerium (III) chloride promoted highly regioselective ring opening of epoxides and aziridines using NaN3 in acetonitrile: a facile synthesis of 1,2-azidoalcohols and 1,2-azidoamines.
Sabitha G, et al.
Organic Letters, 4(3), 343-345 (2002)
Eagleson M.
Concise Encyclopedia Chemistry, 56-56 (1994)
Palladium-Catalyzed Oxidative Arylalkylation of Activated Alkenes: Dual C-H Bond Cleavage of an Arene and Acetonitrile.
Wu T, et al.
Angewandte Chemie (International Edition in English), 50(52), 12578-12581 (2011)

Articles

Solvent Miscibility Table

Substances are said to be miscible in one another if they dissolve to form a uniform solution. Bookmark or download our miscibility table for common lab solvents.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service