Merck

F6754

Sigma-Aldrich

铁蛋白 来源于人类肝脏

Type IV, 10 μg/mL

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CAS号:
MDL编号:
NACRES:
NA.61

生物来源

human liver

质量水平

无菌性

0.2 μm filtered

类型

Type IV

检测方案

≥95% (SDS-GE)

形式

liquid

分子量

H subunit ~21 kDa
L subunit ~19 kDa
~440 kDa (a shell of 24 protein subunits (apoferritin) and a core of Fe3+ ions)

包装

vial of 2 μg

浓度

10 μg/mL

UniProt登记号

储存温度

2-8°C

Gene Information

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此商品
F7879V8379F4503
assay

≥95% (SDS-GE)

assay

-

assay

-

assay

-

form

liquid

form

liquid

form

lyophilized powder

form

saline solution

mol wt

H subunit ~21 kDa, L subunit ~19 kDa, ~440 kDa (a shell of 24 protein subunits (apoferritin) and a core of Fe3+ ions)

mol wt

-

mol wt

A subunit 75 kDa, B subunit 65 kDa

mol wt

H subunit ~21 kDa, L subunit ~19 kDa

packaging

vial of 2 μg

packaging

-

packaging

pkg of 50 μg

packaging

-

concentration

10 μg/mL

concentration

10 mg/mL in 0.15 M NaCl

concentration

-

concentration

-

一般描述

铁蛋白包含24个亚基,属于铁蛋白样双铁羧酸蛋白质超家族。铁蛋白由重链(H)和轻链(L)亚基组成。肝铁蛋白主要由轻链亚基组成,脾为重链。轻链亚基定位于人染色体9q13.33, 重链为11q12.3。

应用

人肝脏铁蛋白已用作体积排阻高效液相色谱中的蛋白模型,并用于合成纳米孔转位研究。还用于检测其对虾(凡纳滨对虾/Litopenaeus vannamei)的白斑综合征病毒易感性的影响。

生化/生理作用

广泛的储铁蛋白在铁代谢中起关键作用。其用作细胞内的铁储备(特别是在脾脏、肝脏、肠粘膜和骨髓中)并参与铁解毒。 研究表明,铁蛋白铁的掺入是由与铁蛋白 H 亚基相关的铁氧化酶活性和与铁蛋白 L 亚基相关的成核中心介导的。 从铁蛋白释放铁在铁依赖性脂质过氧化中具有重要作用,并且可能在体内促成自由基诱导的细胞损伤。因此,通过结合铁,铁蛋白可以起抗氧化剂的作用。
铁蛋白是宿主防御体系的一部分,在动物的抗病毒感染应答中起作用。铁蛋白的异常水平与前列腺、乳腺和大脑等多个部位的肿瘤有关。炎症和巨噬细胞活化综合征(MAS)会导致铁蛋白浓度升高。轻链亚基突变会导致神经退行性疾病、遗传性铁蛋白病。

外形

溶液,pH 8.0,含10 mM Tris、150 mM NaCl和0.1%叠氮化钠。

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable


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