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Merck

T6376

曲安奈德

Glucocorticoid agonist

别名:

9α-Fluoro-11β,16α,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, Fluoxyprednisolone

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50 MG

$82.10

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关于此项目

经验公式（希尔记法）:
C21H27FO6
化学文摘社编号:
124-94-7
分子量:
394.43
EC號碼:
204-718-7
MDL號碼:
MFCD00010477
分類程式碼代碼:
12352200
PubChem物質ID:
24278749
NACRES:
NA.77

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产品名称

曲安奈德,

mp

262-263 °C (lit.)

溶解度

DMF: soluble 20 mg/mL
methanol: soluble 5 mg/mL
DMSO: soluble (Refer citation 16)

起源

Abbott

SMILES 字串

[H][C@@]12C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1

InChI 密鑰

GFNANZIMVAIWHM-OBYCQNJPSA-N

基因資訊

human ... NR3C1(2908), PTGS2(5743)

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此商品
T6501T18999901676000
曲安奈德

Sigma-Aldrich

T6376

曲安奈德

醋酸曲安奈德 analytical standard

Supelco

T6501

醋酸曲安奈德

曲安奈德 European Pharmacopoeia (EP) Reference Standard

T1899990

曲安奈德

曲安奈德 United States Pharmacopeia (USP) Reference Standard

USP

1676000

曲安奈德

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

-

solubility

DMF: soluble 20 mg/mL, DMSO: soluble (Refer citation 16), methanol: soluble 5 mg/mL

solubility

-

solubility

-

solubility

-

originator

Abbott

originator

-

originator

-

originator

-

mp

262-263 °C (lit.)

mp

-

mp

262-263 °C (lit.)

mp

262-263 °C (lit.)

Gene Information

human ... NR3C1(2908), PTGS2(5743)

Gene Information

human ... NR3C1(2908)

Gene Information

human ... NR3C1(2908)

Gene Information

human ... NR3C1(2908)

應用

Triamcinolone has been used as a corticosteroid standard for LC-MS-MS analysis[1]. Triamcinolone has also been used to study its effect on IgG and IgE levels in peripheral blood mononuclear cells (PBMCs)[2]

生化／生理作用

Triamcinolone is a synthetic glucocorticoid agonist; induces gene expression and apoptosis; inhibits prostaglandin synthesis; impairs tumor necrosis factor (TNF)-α-induced degradation of κB-α; potentiates the differentiation-inducing effects of bone morphogenetic proteins (BMP-2, -4, -6).

特點和優勢

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形圖

Health hazard
GHS08

訊號詞

Warning

危險聲明

H351

防範說明

P281

危險分類

Carc. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBD8306V
MKCQ7236
MKCP2834
MKCN0750
MKCL3052

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M O Aksoy et al.
The Journal of allergy and clinical immunology, 103(6), 1081-1091 (1999-06-09)
Airway epithelial cells are among the first cells to come in contact with aerosolized corticosteroids. However, the relative potencies and time course of action of the several commonly used aerosolized corticosteroids on eicosanoid production by airway epithelial cells are unknown.
F H Klebl et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 24(11), 1022-1029 (1994-11-01)
Hydrocortisone (HC) as well as its synthetic derivatives have been shown to strongly enhance interleukin-4 (IL-4)-induced in vitro IgE synthesis. To investigate possible effects on IgG subclasses, peripheral blood mononuclear cells (PBMC) were incubated with different glucocorticosteroids in the absence
Suresh Ambati et al.
mBio, 12(1) (2021-02-25)
Invasive fungal diseases cause millions of deaths each year. There are currently approximately 300,000 acute cases of aspergillosis, most of which result from a pulmonary infection of immunocompromised patients by the common soil organism and opportunistic pathogen Aspergillus fumigatus Patients
Wai-Leung Langston Suen et al.
Journal of controlled release : official journal of the Controlled Release Society, 167(1), 21-28 (2013-01-15)
We are proposing folate-decorated polymeric nanoparticles as carriers of poorly soluble drug molecules for intracellular and prolonged delivery to retinal pigment epithelium (RPE) cells. RPE is a monolayer of epithelial cells that forms the outer blood-retinal barrier in the posterior
Thøger Persson Krogh et al.
The American journal of sports medicine, 41(3), 625-635 (2013-01-19)
Lateral epicondylitis (LE) is a common musculoskeletal disorder for which an effective treatment strategy remains unknown. To examine whether a single injection of platelet-rich plasma (PRP) is more effective than placebo (saline) or glucocorticoid in reducing pain in adults with
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Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

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