T7383
丁卡因
≥98% (TLC)
别名:
4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯
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关于此项目
经验公式（希尔记法）:
C15H24N2O2
化学文摘社编号:
分子量:
264.36
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.32
跳至
生物源
synthetic (organic)
品質等級
化驗
≥98% (TLC)
形狀
powder
技術
toxicology assay: suitable
儲存溫度
2-8°C
SMILES 字串
CCCCNc1ccc(cc1)C(=O)OCCN(C)C
InChI
1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
InChI 密鑰
GKCBAIGFKIBETG-UHFFFAOYSA-N
基因資訊
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1 of 4
此商品 | 1649991 | Y0002117 | T7508 |
|---|---|---|---|
| form powder | form - | form - | form - |
| assay ≥98% (TLC) | assay - | assay - | assay ≥99% |
| technique(s) toxicology assay: suitable | technique(s) - | technique(s) - | technique(s) - |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
| biological source synthetic (organic) | biological source - | biological source - | biological source - |
一般說明
Tetracaine belongs to the amino-ester class and has a pKa of 8.46.[1]
應用
眼用局部麻醉药；用于脊髓麻醉
Tetracaine can be used as a research tool for studying E-C coupling in both skeletal as well as cardiac muscle.[2] The product is a local anaesthetic drug used for studying the impact of numerous drugs on Tumour-necrosis-factor (TNF)-mediated cytotoxicity as well as TNF-induced arachidonic acid release.[3]
生化／生理作用
阻断 Ca2+ 从肌浆网的电压敏感性释放。
Tetracaine also refers as 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester interfere with calcium movement in muscle and non-muscle cells and can inhibit potassium-induced as well as caffeine-induced shortening of outer hair cells (OHC′s). But, the product can′t inhibit electrically-induced shortening of OHC′s.[6]The product can also stimulate caspase activation and inhibits pro-survival signalling pathways which in turn induce human renal cell apoptosis.[7]
準備報告
250 mg of tetracaine dissolves in 5 ml of EtOH to yield a clear, colorless solution. The product is also soluble in chloroform and ether at a ratio of 1:2 and in ethanol at 1:5. It is very slightly soluble in water.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
Tetracaine, a local anesthetic, preferentially induces translational inhibition with processing body formation rather than phosphorylation of eIF2alpha in yeast
Araki T, et al.
Current Genetics, 61(1), 43-53 (2015)
Insect morphogenetic hormones and developmental mechanisms in the nematode, Nematospiroides dubius.
R D Dennis
Comparative biochemistry and physiology. A, Comparative physiology, 53(1), 53-56 (1976-01-01)
Pharmacological considerations for Regional Anesthesia
Principles and Practice of Opthalmic Anesthesia (2018)
Lactobacillus gasseri in the upper small intestine impacts an ACSL3-dependent fatty acid-sensing pathway regulating whole-body glucose homeostasis
Bauer PV, et al.
Cell Metabolism, 27(3), 572-587 (2018)
H Thomas Lee et al.
American journal of nephrology, 23(3), 129-139 (2003-02-15)
Renal cell apoptosis contributes significantly to the pathogenesis of acute renal failure. Local anesthetics induce apoptosis in neuronal and lymphocytic cell lines. We examined the effects of chronic (48 h) local anesthetic treatment (lidocaine, bupivacaine and tetracaine) on human proximal
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