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Merck

E18425

氰乙酸乙酯

≥98%

同義詞:

α-氰基乙酸乙酯, 2-氰基乙酸乙酯, 3-乙氧基-3-氧代丙腈, 丙二酸乙酯腈, 氰基乙酸乙酯, 氰基乙酸酯, (乙氧基碳基)乙腈

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線性公式:
NCCH2COOC2H5
CAS 編號:
分子量::
113.11
Beilstein:
605871
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

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蒸汽密度

3.9 (vs air)

品質等級

蒸汽壓力

1 mmHg ( 67.8 °C)

化驗

≥98%

形狀

liquid

折射率

n20/D 1.418 (lit.)

bp

208-210 °C (lit.)

mp

−22 °C (lit.)

密度

1.063 g/mL at 25 °C (lit.)

SMILES 字串

CCOC(=O)CC#N

InChI

1S/C5H7NO2/c1-2-8-5(7)3-4-6/h2-3H2,1H3

InChI 密鑰

ZIUSEGSNTOUIPT-UHFFFAOYSA-N

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本產品
10842154305528440
assay

≥98%

assay

99%

assay

96%

assay

≥97.0% (GC)

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

form

liquid

form

-

form

-

form

-

refractive index

n20/D 1.418 (lit.)

refractive index

n20/D 1.417 (lit.)

refractive index

n20/D 1.445 (lit.)

refractive index

n20/D 1.420

mp

−22 °C (lit.)

mp

−13 °C (lit.)

mp

-

mp

-

bp

208-210 °C (lit.)

bp

204-207 °C (lit.)

bp

217 °C (lit.)

bp

40-42 °C/0.1 mmHg (lit.)

一般說明

氰基乙酸乙酯是酯。报道了氰基乙酸乙酯与醛的Knoevenagel 缩合反应。[1]研究人员报道了氰基乙酸乙酯与醛、P2O5、哌啶和氯苯的微波增强Knoevenegal 缩合反应。

氰基乙酸乙酯广泛用作有机合成中的合成砌块,用于生成活性药物成分。[2][3]

應用

氰基乙酸乙酯可用于合成乙醛酸乙酯。[4]通过将氨基嫁接到 NaX和CsNaX 沸石上获得的沸石催化剂,并将其用于研究微反应器中的Knoevenagel 缩合反应。[5]

包裝

封装在玻璃瓶中

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

230.0 °F

閃點(°C)

110 °C

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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分析證明 (COA)

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The Knoevenagel condensation of aromatic aldehydes with malononitrile or ethyl cyanoacetate in the presence of CTMAB in water.
Wang S, et al.
Synthetic Communications, 31(5), 673-677 (2001)
Microwave Enhanced Knoevenagel Condensation of Ethyl Cyanoacetate with Aldehydes.
Kim S-Y, et al.
Synthetic Communications, 27(4), 533-541 (1997)
Electrogenerated bases VII. Novel syntheses of ethyl glyoxalate and diethyl ketomalonate via electrogenerated superoxide.
Sugawara M and Baizer MM.
Tetrahedron Letters, 24(22), 2223-2226 (1983)
Yuya Oka et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(39), 9362-9368 (2017-05-18)
Mesoporous basic Mg-Al mixed metal oxides (MMOs) with a high surface area and large pore size have been prepared through the assembly of monodispersed layered double hydroxide nanoparticles (LDHNPs) with block copolymer templates. The particle sizes of the LDHNPs were
Korany A Ali et al.
Mini reviews in medicinal chemistry, 18(8), 717-727 (2017-04-27)
In this study, synthesis, molecular docking and anticancer screening of new series of substituted heterocycles with trimethoxy phenyl scaffold as Combretastatin analogues were described. Substituted pyridines were synthesized via the reaction of (E)-3-(dimethylamino)-1-(3,4,5- trimethoxyphenyl)prop-2-en-1-one (2) with active methylene reagents. Substituted

文章

Knoevenagel Condensation 是以 Emil Knoevenagel 命名的有機反應。它是典型的 C-C 鍵形成反應,也是 Aldol Condensation 的改良。

Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

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    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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