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Merck

05-797R

抗-磷酸化-Erk1/2（Thr202/Tyr204，Thr185/Tyr187）抗体，重组克隆AW39R，兔单克隆

clone AW39R, Upstate®, from rabbit

同義詞:

Erk1, Erk2, p44-MAPK, p42-MAPK, MAPK2, PRKM2, p41mapk, PRKM1, p44, ERK2, P42MAPK, ERK, p42, MAPK1, ERT1, ERT2, Mitogen-activated protein kinase, MAP Kinase 2, MAP Kianse 1, MAPK

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分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

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生物源

rabbit

品質等級

100

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

AW39R, monoclonal

物種活性

human, mouse, rat

製造商／商標名

Upstate®

技術

multiplexing: suitable
western blot: suitable

同型

IgG

NCBI登錄號

NP_002736
NP_002737

UniProt登錄號

P27361
P28482

運輸包裝

dry ice

目標翻譯後修改

phosphorylation ((pThr202/pTyr204), (pThr185/pTyr187))

基因資訊

human ... MAPK3(5595)
mouse ... Mapk3(26417)
rat ... Mapk3(50689)

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本產品
04-797FCMAB100P05-957-I
抗-磷酸化-Erk1/2（Thr202/Tyr204，Thr185/Tyr187）抗体，重组克隆AW39R，兔单克隆 clone AW39R, Upstate®, from rabbit

Sigma-Aldrich

05-797R

抗-磷酸化-Erk1/2（Thr202/Tyr204，Thr185/Tyr187）抗体，重组克隆AW39R，兔单克隆

抗磷酸化-MAP激酶1/2 (Erk1/2)(Thr185/Tyr187) 抗体，克隆AW39 clone Aw39, Upstate®, from rabbit

Sigma-Aldrich

04-797

抗磷酸化-MAP激酶1/2 (Erk1/2)(Thr185/Tyr187) 抗体，克隆AW39

Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE clone AW39R, Milli-Mark®, from rabbit

Sigma-Aldrich

FCMAB100P

Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE

抗ERK1 / MAPK3抗体，CT抗体，克隆UP-158-22-3-10 culture supernatant, clone UP-158-22-3-10, from rabbit

Sigma-Aldrich

05-957-I

抗ERK1 / MAPK3抗体，CT抗体，克隆UP-158-22-3-10

Gene Information

human ... MAPK3(5595)
mouse ... Mapk3(26417)
rat ... Mapk3(50689)

Gene Information

human ... MAPK1(5594)
rat ... Mapk1(116590)

Gene Information

human ... MAPK3(5595)

Gene Information

human ... MAPK3(5595)

species reactivity

human, mouse, rat

species reactivity

human, rat

species reactivity

mouse, rat

species reactivity

rat, human, mouse

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

antibody form

purified immunoglobulin

antibody form

culture supernatant

antibody form

purified antibody

antibody form

culture supernatant

clone

AW39R, monoclonal

clone

Aw39, monoclonal

clone

AW39R, monoclonal

clone

UP-158-22-3-10, monoclonal

technique(s)

multiplexing: suitable, western blot: suitable

technique(s)

multiplexing: suitable, western blot: suitable

technique(s)

flow cytometry: suitable, western blot: suitable

technique(s)

western blot: suitable

一般說明

Erk1 (p44) (~44 kDa) 和Erk2 (p42) (~42 kDa)。
Erk（细胞外信号相关激酶）是两个高度同源的蛋白质家族，分别称为Erk1（p44，MAPK3）和Erk2（p42，MAPK1），它们都在同一途径中起作用。 这两种蛋白通常统称为Erk1/2或p44/p42 MAP激酶。Erk途径被认为是经典的，经典的MAPK（促分裂原活化蛋白激酶）信号传导途径。它是一种进化上保守的途径，通过促进细胞增殖和防止细胞凋亡来控制并作为关键调节剂来控制生长和存活。Erk参与许多基本细胞过程的控制，包括细胞增殖，存活，分化，凋亡，运动性和代谢。Erk通过受体酪氨酸激酶（RTK）的生长因子刺激，GPCR和/或整联蛋白刺激而激活。这会激活Ras-Raf-MEK-Erk途径，从而导致TxY基序上的Erk1/2（p44/p42）磷酸化/激活（Erk1 & Erk2分别为Thr202/Tyr204和Thr185/Tyr187）。

免疫原

一种磷酸化肽，对应于人磷酸化-ERK1/2激活环中pTEpY基序周围的氨基酸，其中Thr和Tyr残基被磷酸化
表位：激活环中的pTEpY

應用

抗磷酸化Erk1/2（Thr202/Tyr204抗体，Thr185/Tyr187），重组克隆AW39R检测磷酸化Erk1/2的水平（Thr202/Tyr204&已发表，&经验证可用于Mplex & WB。
研究子类别
MAP激酶

激酶&磷酸酶
研究类别
信号传导

生化／生理作用

仅当Erk 1 & 2在其TxY激活基序上双重磷酸化时才能识别Erk 1 2。

外觀

形式：纯化
蛋白A纯化
蛋白A纯化的免疫球蛋白溶于30％甘油，0.07M Tris-甘氨酸（pH 7.4）、0.105 M NaCl，0.035％叠氮化钠作为防腐剂的溶液中。

準備報告

自收到之日起在-20°C可稳定保存1年。处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于 -20°C。避免反复冻融循环，以免损坏 IgG 和影响产品性能。

分析報告

对照
PDGF处理的NIH/3T3细胞裂解液
已通过免疫印迹对PDGF处理的NIH/3T3细胞裂解液进行常规评估

其他說明

替代：05-797

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

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存取文件庫

Jiamin Cheng et al.
Oncotarget, 7(15), 20597-20611 (2016-03-12)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death. This high mortality has been commonly attributed to the presence of residual cancer stem cells (CSCs). Meanwhile, MEK1 signaling is regarded as a key molecular in HCC maintenance and
Wen-Tsan Chang et al.
Molecules (Basel, Switzerland), 22(5) (2017-05-23)
Hepatocellular carcinoma (HCC) is a leading cancer worldwide. Advanced HCCs are usually resistant to anticancer drugs, causing unsatisfactory chemotherapy outcomes. In this study, we showed that a 4-phenoxyphenol derivative, 4-[4-(4-hydroxyphenoxy)phenoxy]phenol (4-HPPP), exerts an inhibitory activity against two HCC cell lines
Dhia Azzouz et al.
Cell death discovery, 4, 51-51 (2018-05-08)
NETosis is a unique form of neutrophil death that differs from apoptosis and necrosis. However, whether NETosis and apoptosis can occur simultaneously in the same neutrophil is unknown. In this paper, we show that increasing doses of ultraviolet (UV) irradiation
Crescent R Isham et al.
The Journal of clinical endocrinology and metabolism, 99(6), E936-E943 (2014-03-19)
Vascular endothelial growth factor-targeted kinase inhibitors have emerged as highly promising therapies for radioiodine-refractory metastatic differentiated thyroid cancer. Unfortunately, drug resistance uniformly develops, limiting their therapeutic efficacies and thereby constituting a major clinical problem. To study acquired drug resistance and
Dusan Matusica et al.
Journal of cell science, 129(3), 517-530 (2015-10-28)
The p75 neurotrophin receptor (p75(NTR); also known as NGFR) can mediate neuronal apoptosis in disease or following trauma, and facilitate survival through interactions with Trk receptors. Here we tested the ability of a p75(NTR)-derived trophic cell-permeable peptide, c29, to inhibit
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