Alendronate, Sodium Salt

Name: Alendronate, Sodium Salt
Brand: MM

≥98% (NMR), farnesyl disphosphate synthase inhibitor, solid

同義詞:

Alendronate, Sodium Salt, Alendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate

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經驗公式（希爾表示法）:

C₄H₁₂NNaO₇P₂ · 3H₂O

CAS 編號:

121268-17-5

分子量：:

325.12

MDL號碼:

MFCD01748233

分類程式碼代碼:

12352200

NACRES:

NA.77

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產品名稱

Alendronate, Sodium Salt, An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.

品質等級

100

描述

Merck USA index - 14, 229

化驗

≥98% (NMR)

形狀

solid

製造商／商標名

Calbiochem^®

儲存條件

OK to freeze
desiccated (hygroscopic)

顏色

white

溶解度

water: 10 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

SMILES 字串

[Na+].[P](=O)([O-])(O)[C@@]([P](=O)(O)O)(O)CCCN.O.O.O

InChI

1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1

InChI 密鑰

DCSBSVSZJRSITC-UHFFFAOYSA-M

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本產品	506600	233183	251680
Sigma-Aldrich 126855 Alendronate, Sodium Salt	Sigma-Aldrich 506600 Pamidronate, Disodium Salt	Sigma-Aldrich 233183 Clodronate, Disodium Salt	Sigma-Aldrich 251680 丹曲林，钠盐
form solid	form solid	form solid	form solid
assay ≥98% (titration)	assay ≥98% (HPLC)	assay ≥97% (titration)	assay ≥95% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 10-30°C
solubility water: 10 mg/mL	solubility water: 10 mg/mL	solubility water: 1 mg/mL	solubility DMSO: 3 mg/mL, aqueous base: soluble

一般說明

An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts. Shown to induce apoptosis of osteoclasts and macrophages. Inhibits farnesyl disphosphate synthase (IC₅₀ = 460 nM with purified enzyme and 1.7 µM with cell extracts). Also shown to inhibit migration, cell adhesion, and invasion of cells (IC₅₀ = 1 pM in prostate cancer cell invasion assays). Efficiently chelates metal ions and functions as a matrix metalloprotease (MMP) inhibitor (IC₅₀ = 40-70 µM).

生化／生理作用

Cell permeable: no

Primary Target
Farnesyl diphosphate synthase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 460 nM against farnesyl diphosphate synthase; ~ 40 - 70 µM as as a broad-spectrum MMP inhibitor; ~ 1 pM against in vitro invasion of prostate cancer cells

準備報告

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Lehenkari, P.P., et al. 2002. Mol. Pharmacol.62, 1255.
Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.
Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys.373, 231.
Smith, R., et al. 1971. Lancet1, 945.
Fleisch, H., et al. 1969. Nature223, 211.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Toxicity: Harmful (C)

象形圖

GHS07

訊號詞

Warning

危險聲明

H302

防範說明

P264 - P270 - P301 + P312 - P501

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）