跳轉至內容
Merck

324410

Dynasore

≥98% (HPLC), solid, dynamin inhibitor, Calbiochem®

同義詞:

发动蛋白抑制剂I ，Dynasore

Slide 1 of 1
登入 查看組織和合約定價

選擇尺寸

暫時無法取得訂價和供貨情況

關於此項目

經驗公式（希爾表示法）:
C18H14N2O4
CAS 編號:
304448-55-3
分子量：:
322.31
MDL號碼:
MFCD00292551
分類程式碼代碼:
12352200
NACRES:
NA.77

重要文件

檢視所有文件

跳轉至

技術服務
需要援助？我們經驗豐富的科學家團隊隨時樂意為您提供支援。
讓我們為您提供幫助

產品名稱

发动蛋白抑制剂I ，Dynasore, The Dynamin Inhibitor I, Dynasore, also referenced under CAS 304448-55-3, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

pale yellow

溶解度

DMSO: 16 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

SMILES 字串

N(\N=C\c3cc(c(cc3)O)O)C(=O)c1cc2c(cc1O)cccc2

InChI

1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+

InChI 密鑰

SYNDQCRDGGCQRZ-VXLYETTFSA-N

相關類別

比較類似項目

查看完整比較

Show Differences

1 of 4

本產品
324413324414324411
发动蛋白抑制剂I ，Dynasore The Dynamin Inhibitor I, Dynasore, also referenced under CAS 304448-55-3, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Sigma-Aldrich

324410

发动蛋白抑制剂I ，Dynasore

Dynamin Inhibitor IV, Hydroxy-Dynasore The Dynamin Inhibitor IV, Hydroxy-Dynasore controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Sigma-Aldrich

324413

Dynamin Inhibitor IV, Hydroxy-Dynasore

Dynamin Inhibitor V, 34-2 The Dynamin Inhibitor V, 34-2 controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Sigma-Aldrich

324414

Dynamin Inhibitor V, 34-2

Dynamin Inhibitor II, MiTMAB The Dynamin Inhibitor II, MiTMAB, also referenced under CAS 1119-97-7, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Sigma-Aldrich

324411

Dynamin Inhibitor II, MiTMAB

form

solid

form

solid

form

solid

form

solid

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥99% (HPLC)

assay

≥99% (titration)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic)

一般說明

一种细胞可渗透的缩氨基脲化合物，可抑制发动蛋白1/2（IC50 ~15 µM）和Drp1的GTPase活性，对其他两种小GTPases（MxA和Cdc42）没有显著的影响。Dynasore已被用来阐明发动蛋白在网格蛋白包被的和突触小泡介导的内吞作用中的作用。抑制相对于GTP是非竞争性的，并且抑制剂靶位点可能位于GTPase结构域中。显示抑制从质膜上去除wt和ΔF508-CFTR。

包裝

用惰性气体包装

準備報告

复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

其他說明

Young, A., et al. 2009.Biochem.J., In press.
Nankoe, S.R., and Sever, S. 2006.Trends Cell Biol.16, 607.
Newton, A.J., et al. 2006.Proc.Natl.Acad.Sci. USA103, 17955.
Macia.E., et al. 2006.Dev.Cell10, 839.
由于该运输中有害物质的性质，您的订单可能需要支付额外的运输费用。某些尺寸的产品可免除其他有害材料的运输费用。请与您当地的销售办事处联系，以获取有关这些费用的更多信息。

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

毒性：环境危害（N）

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Elsa M Reyes-Reyes et al.
Methods in molecular biology (Clifton, N.J.), 2036, 173-186 (2019-08-15)
Oligonucleotides can be designed or evolved to bind to specific DNA, RNA, protein, or small molecule targets and thereby alter the biological function of the target. The therapeutic potential of oligonucleotides targeted to intracellular molecules will depend largely on their
Lina Wang et al.
Immunity, 56(2), 272-288 (2023-02-02)
Self-nonself discrimination is vital for the immune system to mount responses against pathogens while maintaining tolerance toward the host and innocuous commensals during homeostasis. Here, we investigated how indiscriminate DNA sensors, such as cyclic GMP-AMP synthase (cGAS), make this self-nonself
Alba García-Fernández et al.
Pharmaceutics, 14(7) (2022-07-28)
In this article, we report one of the few examples of nanoparticles capable of simultaneously delivering CRISPR-Cas9 gene-editing machinery and releasing drugs for one-shot treatments. Considering the complexity of inflammation in diseases, the synergistic effect of nanoparticles for gene-editing/drug therapy
Gang Xi et al.
Kidney international reports, 9(2), 451-463 (2024-02-12)
Podocyte slit diaphragms are an important component of the glomerular filtration barrier. Podocyte injury frequently includes defects in slit diaphragms, and various mechanisms for these defects have been described, including altered endocytic trafficking of slit diaphragm proteins or oxidative stress.
Maxwell S DeNies et al.
Communications biology, 3(1), 789-789 (2020-12-20)
It has become increasingly apparent that G protein-coupled receptor (GPCR) localization is a master regulator of cell signaling. However, the molecular mechanisms involved in this process are not well understood. To date, observations of intracellular GPCR activation can be organized
查看所有相關論文

Questions

Reviews

No rating value

Active Filters

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務